GSR Antibody

Code CSB-PA436998
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA436998(GSR Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA436998(GSR Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Jurkat cells, Hela cells, A549 cells, Primary antibody: CSB-PA436998(GSR Antibody) at dilution 1/750, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds
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Product Details

Uniprot No.
Target Names
GSR
Alternative Names
GLR1 antibody; GLUR antibody; Glutathione reductase antibody; Glutathione reductase mitochondrial antibody; Glutathione reductase; mitochondrial antibody; GR antibody; Gr1 antibody; GRase antibody; GRD 1 antibody; GRD1 antibody; GSHR_HUMAN antibody; GSR antibody; MGC78522 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Fusion protein of Human GSR
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:10000
WB 1:1000-1:5000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Maintains high levels of reduced glutathione in the cytosol.
Gene References into Functions
  1. It has been shown that acute aerobic exercise activates Nrf2 in young men, irrespective of training intensity, but that high-intensity exercise demonstrated a greater effect on increasing glutathione reductase activity which could indicate improved redox potential. PMID: 28693341
  2. GSR expression was higher in TMZ-resistant cells than in sensitive cells. GSR silencing in drug-resistant cells improved the sensitivity of cells to TMZ or cisplatin. Over-expression resulted in resistance. GSR partially prevented the oxidative stress caused by L-buthionine -sulfoximine. The action of GSR in drug resistance is associated with the modulation of redox homeostasis. High GSR correlated with lower survival. PMID: 29105080
  3. Plasma glutathione reductase (GR) activity was correlated with erythrocyte GR activity and the erythrocyte reduced glutathione/glutathione disulfide ratio. A decrease in plasma GR activity was associated with an increase in mortality in septic shock. PMID: 26316444
  4. Glutathione reductase reduces mitochondrial protein mitoNEET [2Fe-2S] clusters. PMID: 25645953
  5. The recurrence of benign tumors of mammary gland occurred predominantly in women-carriers of mutant alleles with polymorphism rs8190924 of gene GSR and AA rs3763511of gene DKK4. PMID: 26419038
  6. GSR was the most significant single SNP association with systemic lupus erythematosus in African Americans. PMID: 23637325
  7. The results demonstrate for the first time that glutathione reductase gene polymorphisms are significantly associated with bone mineral density. PMID: 22089180
  8. Up-regulation of CAT and GR activity resulted in an increase in total antioxidant activity in A549 after exposure to B(a)P. PMID: 21417634
  9. Human eye lenses were dissected into discrete regions that were formed at different stages of life and assayed for activity of lactate dehydrogenase (LDH) and a particularly stable enzyme, glutathione reductase (GR). PMID: 20586645
  10. novel glutathione reductase alternative splice variants PMID: 20628807
  11. GR deficiency and drug-induced GR inhibition may protect from malaria by inducing enhanced ring stage phagocytosis rather than by impairing parasite growth directly [case study] PMID: 19806191
  12. Malignant lung tumors (squamous cell carcinoma and adenocarcinoma) had increased activity of this enzyme. PMID: 12447480
  13. activities of catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx) and superoxide dismutase (SOD) were decreased during intense physical exercise PMID: 12516882
  14. An oxidative stress marker after kidney transplantation PMID: 12826156
  15. Patients with chronic alcoholism (PCA) of stage II have increased glutathione reductase (GR) activity in neutrophils, lymphocytes and monocytes compared with that in the cells of healthy donors PMID: 12838767
  16. GR activity in COPD and chest osteomyelitis decreased by 40% and more, lung tumors--by 32-36%. PMID: 12838770
  17. serum concentrations in patients with chronic lymphocytic leukemia PMID: 14637279
  18. Decreased activities of erythrocyte glutathione reductase is associated with cerebral palsy PMID: 15978628
  19. Data show that both glutathione and glutathione reductase are inducible by D3T, and that upregulation of GSH biosynthesis underlies D3T-mediated cytoprotection against ROS/RNS-elicited injury to human vascular smooth muscle cells. PMID: 17206382
  20. Inhibitory effects of several antibiotics on purified human erythrocyte glutathione reductase has been investigated. PMID: 18341267
  21. Data report synchrotron-based cryocrystallographic studies of natural substrate complexes of the flavoenzyme human glutathione reductase at nominal resolutions between 1.1 and 0.95 A that reveal new aspects of its mechanism. PMID: 18638483
  22. higher glutathione reductase and total antioxidant capacity were found in end-stage renal disease patients than in controls PMID: 19377255

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Subcellular Location
[Isoform Mitochondrial]: Mitochondrion.; [Isoform Cytoplasmic]: Cytoplasm.
Protein Families
Class-I pyridine nucleotide-disulfide oxidoreductase family
Database Links

HGNC: 4623

OMIM: 138300

KEGG: hsa:2936

STRING: 9606.ENSP00000221130

UniGene: Hs.271510

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