JPT1 Antibody

Code CSB-PA890732HA01HU
Size US$166
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  • Western blot
    All lanes: JPT1 antibody at 2μg/ml + Rat gonad tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 17, 20, 12 kDa
    Observed band size: 17 kDa
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) JPT1 Polyclonal antibody
Uniprot No.
Target Names
JPT1
Alternative Names
Androgen regulated protein 2 antibody; Androgen-regulated protein 2 antibody; ARM2 antibody; Hematological and neurological expressed 1 antibody; Hematological and neurological expressed 1 protein antibody; HN1 antibody; HN1_HUMAN antibody; HN1A antibody
Raised in
Rabbit
Species Reactivity
Human, Rat
Immunogen
Recombinant Human Jupiter microtubule associated homolog 1 protein (2-154AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The JPT1 Antibody (Product code: CSB-PA890732HA01HU) is Non-conjugated. For JPT1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA890732HB01HU JPT1 Antibody, HRP conjugated ELISA
FITC CSB-PA890732HC01HU JPT1 Antibody, FITC conjugated
Biotin CSB-PA890732HD01HU JPT1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation.
Gene References into Functions
  1. Downregulation of MYC abrogated the effect of HN1 overexpression in breast cancer cell lines. Taken together, these data reveal that HN1 promotes the progression of breast cancer by upregulating MYC expression, and might be a therapeutic target for breast cancer. PMID: 28490334
  2. Data report that HN1 is an essential factor for beta-catenin turnover and signaling, augments cell growth and migration in prostate cancer cells. PMID: 25169422
  3. miR-132 is significantly down-regulated in breast cancer tissues and cancer cell lines. Additional study identifies HN1 as a novel direct target of miR-132. MiR-132 down-regulates HN1 expression by binding to the 3' UTR of HN1. PMID: 25450365
  4. HN1 maintains a balance between the androgen-regulated nuclear translocation of androgen receptor and steady-state Akt phosphorylation, predominantly in the absence of androgens. PMID: 22155408
  5. EGF and kinase inhibitors increase HN1 expression, and Silencing of HN1 results in cell cycle alterations in prostate cells. PMID: 21323578
  6. These data suggest a role for Hn1 in the biology of malignant brain tumors. PMID: 19145478

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Subcellular Location
Nucleus. Cytoplasm.
Protein Families
JUPITER family
Tissue Specificity
Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta.
Database Links

HGNC: 14569

KEGG: hsa:51155

STRING: 9606.ENSP00000348316

UniGene: Hs.532803

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