HSPA6 Antibody

Code CSB-PA863082HA01HU
Size US$166
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Image
  • Western blot
    All lanes: HSPA6 antibody at 2µg/ml
    Lane 1: MCF-7 whole cell lysate
    Lane 2: A431 whole cell lysate
    Lane 3: Jurkat whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 72 kDa
    Observed band size: 72 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) HSPA6 Polyclonal antibody
Uniprot No.
Target Names
HSPA6
Alternative Names
Heat shock 70 kDa protein 6 antibody; Heat shock 70 kDa protein B' antibody; Heat shock 70 kDa protein B'' antibody; heat shock 70kD protein 6 (HSP70B') antibody; Heat shock 70kDa protein 6 antibody; HSP70B' antibody; HSP70B-Prime antibody; HSP76_HUMAN antibody; HSPA6 antibody; OTTHUMP00000032372 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Heat shock 70 kDa protein 6 protein (1-637AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The HSPA6 Antibody (Product code: CSB-PA863082HA01HU) is Non-conjugated. For HSPA6 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA863082HB01HU HSPA6 Antibody, HRP conjugated ELISA
FITC CSB-PA863082HC01HU HSPA6 Antibody, FITC conjugated
Biotin CSB-PA863082HD01HU HSPA6 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews
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Applications : IP

Sample type: Human Human neuroblastoma cell

Review: The cells were incubated with cortisol (1 μM) for 60 min. GR was co-immunoprecipitated with anti-Hsp70 and -Hsp90 antibodies (the left side). Expression of Hsp70, Hsp90, GR, and β-actin in total cell lysates is shown in the right side.

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Target Background

Function
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release.
Gene References into Functions
  1. during recovery from neuronal stress, HSPA6 localized with perispeckles that have been characterized as transcription sites; the stress-induced association of HSPA6 with perispeckles displayed the greatest dynamism compared to the interaction of HSPA6 or HSPA1A with other stress-sensitive cytoplasmic and nuclear structures; this suggests involvement of HSPA6 in recovery of neurons from cellular stress PMID: 27527722
  2. In vivo efficacy experiments with HSPA6 siRNA and MFH were performed using the A2780cp20 and HeyA8 ovarian cancer mouse models. A significantly reduction in tumor growth rate was observed with combination therapy. PES and MFH efficacy were also evaluated in the HeyA8 intraperitoneal tumor model, and resulted in robust antitumor effects. PMID: 28223424
  3. measurable HSP70B' was not associated with graft versus host disease following allogeneic hematopoietic cell transplantation PMID: 27020764
  4. endothelial nitric oxide synthase induces heat shock protein HSPA6 (HSP70B') in human arterial smooth muscle cells PMID: 26656590
  5. Data indicate that heat shock protein 90kD(HSP90) inhibition induces heat shock 70kD protein 6 (HSP70B') expression. PMID: 25957766
  6. HSPA6 regulation by TNIP1 occurs in promoter regions lacking binding sites for known TNIP1-repressed transcription factors PMID: 25447897
  7. Hsp70B' also formed complexes with Hsp40 suggesting a common co-chaperone for HSP70 family members. PMID: 20084477
  8. Heat shock protein 70B' (HSP70B') expression and release in response to human oxidized low density lipoprotein immune complexes in macrophages. PMID: 20348092
  9. These findings are likely to be important in pathological conditions in which Hsp70B' contributes to cell survival. PMID: 18229458
  10. Hsp70B' expressed on colon cells after proteasome inhibition was most closely related to Hsp72. They shared 100% AA identity in the peptide-binding region but differed in the lid and C-terminal domains.Hsp70B' appeared to have diverged recently. PMID: 18347947

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Protein Families
Heat shock protein 70 family
Database Links

HGNC: 5239

OMIM: 140555

KEGG: hsa:3310

STRING: 9606.ENSP00000310219

UniGene: Hs.654614

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