JSRP1 Antibody

Code CSB-PA011969GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
JSRP1
Alternative Names
JSRP1 antibody; JP45 antibody; Junctional sarcoplasmic reticulum protein 1 antibody; Junctional-face membrane protein of 45 kDa homolog antibody; JP-45 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human JSRP1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity.
Gene References into Functions
  1. Data indicate that the presence of either one of these JP-45 variants decreased the sensitivity of the dihydropyridine receptor DHPR to activation. PMID: 22927026
  2. The results may be explained by a modulatory effect of JP-45 related to its reported in vitro interaction with the dihydropyridine receptor and the SR Ca(2+) binding protein calsequestrin (CSQ). PMID: 16423849
Subcellular Location
Sarcoplasmic reticulum membrane. Endoplasmic reticulum membrane.
Database Links

HGNC: 24963

OMIM: 608743

KEGG: hsa:126306

STRING: 9606.ENSP00000300961

UniGene: Hs.330742

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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