KY Antibody

Datasheet

Code	CSB-PA012702LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, U87 whole cell lysate All lanes: KY antibody at 3.2µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 64, 42, 73, 76 kDa Observed band size: 64 kDa Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA012702LA01HU at dilution of 1:100 Immunofluorescence staining of Hela cells with CSB-PA012702LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) KY Polyclonal antibody

Uniprot No.

Q8NBH2

Target Names

Alternative Names

KY antibody; KY_HUMAN antibody; Kyphoscoliosis peptidase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Kyphoscoliosis peptidase protein (23-170AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The KY Antibody (Product code: CSB-PA012702LA01HU) is Non-conjugated. For KY Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA012702LB01HU	KY Antibody, HRP conjugated	ELISA
FITC	CSB-PA012702LC01HU	KY Antibody, FITC conjugated
Biotin	CSB-PA012702LD01HU	KY Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

There are currently no reviews for this product.

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Target Background

Function

Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC.

Gene References into Functions

This study shown Kyphoscoliosis peptidase (KY) mutation causes a novel congenital myopathy with core targetoid defects in two bother. PMID: 27484770
Homozygous KY mutation was identified as a cause of progressive hereditary spastic paraplegia. High KY transcript levels were demonstrated in muscular organs and lower expression in the CNS. PMID: 28488683
Homozygous c.1071delG, p.(Thr358Leufs*3) variant of KY causes neuromuscular disorder by introducing a premature stop codon. PMID: 27485408
KY expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614

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Involvement in disease

Myopathy, myofibrillar, 7 (MFM7)

Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line.

Protein Families

Transglutaminase-like superfamily

Tissue Specificity

Highly expressed in skeletal muscle.

Database Links

HGNC: 26576

OMIM: 605739

KEGG: hsa:339855

STRING: 9606.ENSP00000397598

UniGene: Hs.146730

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