MAPK4 Antibody

Datasheet

Code	CSB-PA013457ESR1HU
Size	US$166
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Image	Western blot All lanes: MAPK4 ntibody at 6μg/ml Lane 1: Mouse brain tissue Lane 2: 293T whole cell lysate Lane 3: Jurkat whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 66 kDa Observed band size: 66 kDa Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA013457ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA013457ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MAPK4 Polyclonal antibody

Uniprot No.

P31152

Target Names

MAPK4

Alternative Names

ERK-4 antibody; ERK3 antibody; Erk3 related antibody; ERK4 antibody; Extracellular signal regulated kinase 4 antibody; Extracellular signal-regulated kinase 4 antibody; MAP kinase 4 antibody; MAP kinase isoform p63 antibody; MAPK 4 antibody; MAPK4 antibody; Mitogen activated protein kinase 4 antibody; Mitogen-activated protein kinase 4 antibody; MK04_HUMAN antibody; p63 MAPK antibody; p63-MAPK antibody; p63MAPK antibody; PRKM4 antibody; Protein kinase; mitogen-activated; 4 antibody; Protein-tyrosine kinase ERK3-related antibody; RMNK2 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Mitogen-activated protein kinase 4 protein (348-587AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle.

Gene References into Functions

Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway. PMID: 21177870
Data defined a novel MK5 interaction motif (FRIEDE) within both ERK4 and ERK3 that is essential for binding to the C-terminal region of MK5. PMID: 19473979
Data show that in contrast to ERK3, ERK4 (MAPK4) is a stable protein and binds to MAPKAPK-5. Interaction of ERK4 with MAPKAPK-5 leads to translocation of MAPKAPK-5 to the cytoplasm and to its activation by phosphorylation. ERK4 can form dimers with ERK3. PMID: 16973613

Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily

Tissue Specificity

High expression in heart and brain.

Database Links

HGNC: 6878

OMIM: 176949

KEGG: hsa:5596

STRING: 9606.ENSP00000383234

UniGene: Hs.433728

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Phage Display Service

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Protein Service

Gene Synthesis Service

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Protein Phosphorylation: The Dynamic Language of Cellular Regulation Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

IL-17 signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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