MCM3AP Antibody

1. The identification of MCM3AP variants in affected individuals from multiple centres establishes it as a disease gene for childhood-onset recessively inherited Charcot-Marie-Tooth neuropathy with intellectual disability. PMID: 28633435
2. MCM3AP and POMP Mutations Cause a DNA-Repair and DNA-Damage-Signaling Defect in an Immunodeficient Child PMID: 26615982
3. These results indicated that the GANP protein is associated with breast cancer resistance. PMID: 26749495
4. GANP is induced in activated T4 cells & physically interacts with A3G. GANP is encapsidated in HIV-1 virions & modulates A3G packaging into the cores. Upregulation increases A3G-catalyzed viral G-->A hypermutation, suppressing infectivity. PMID: 24198285
5. A homozygous potentially pathogenic variant (c.2743G>A) was identified, which encodes amino acid Lys, instead of conserved Glu, at the position 915, in patients with mild intellectual disability. PMID: 24123876
6. GANP-mediated chromatin modification promotes transcription complex recruitment and positioning at immunoglobulin variable loci to favour AID targeting. PMID: 23652018
7. The cellular protein MCM3AP is required for inhibition of cellular DNA synthesis by the IE86 protein of human cytomegalovirus. PMID: 23094019
8. HBV DNA integration sites into human genome were random, and MCM3AP was a new site. PMID: 20714864
9. GANP, a homologue of yeast Sac3 that is involved in mRNA export, is indispensable for ensuring the stability of human genomic DNA and GANP knockdown causes apoptosis and necrosis of p53-insufficient cancer cells. PMID: 22395445
10. GANP transgene may play a critical role in Lyn tyrosine-protein kinase-mediated signaling during selection of high-affinity B cells in peripheral lymphoid organs. PMID: 22942428
11. MCM3AP and GANP are different proteins, occupying different locations in the cell and transcribed from different promoters PMID: 21195085
12. Data show that human germinal center-associated nuclear protein (GANP) is critically involved in cell proliferation at the mitotic phase through its selective support of shugoshin-1 mRNA export. PMID: 20384790
13. GANP may serve as an essential link required to transport AID to B-cell nuclei and to target AID to actively transcribed IgV regions PMID: 20507984
14. GANP depletion inhibits mRNA export, with retention of mRNPs and NXF1 in punctate foci within the nucleus. PMID: 20005110
15. inhibits initiation of DNA replication via binding to MCM3 PMID: 12226073
16. plays a certain important role in the maturation of immunoglobulin or selection of B cells in germinal centers during the immune response to TD-Ag. A selective function of GANP molecule on B cell proliferation and differentiation might exist. PMID: 12885157
17. abnormal over-expression of GANP together with AID might be associated with rigorous DNA damage, potentially causing the malignant development of Cholangiocarcinoma (CCAs) during long-term inflammation. PMID: 19578742
18. GANP protects cells from cellular senescence caused by DNA damage and that a significant decrease in GANP expression leads to malignancy by generating hyperploidy and chromosomal instability (CIN). PMID: 19686285

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HGNC: 6946

OMIM: 603294

KEGG: hsa:8888

STRING: 9606.ENSP00000291688

UniGene: Hs.389037