MDFI Antibody

Code CSB-PA003210
Size US$100
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  • Western Blot analysis of Jurkat cells using MDFI Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
MDFI
Alternative Names
MDFI antibody; MyoD family inhibitor antibody; Myogenic repressor I-mf antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the Internal region of Human MDFI.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.
Gene References into Functions
  1. MDFI was significantly hypermethylated in colorectal cancer tissues when compared with adjacent normal colorectal tissues. PMID: 28782576
  2. I-mfa domain proteins may be involved in their oncogenic functions by negatively regulating their transcriptional activities. PMID: 21664411
  3. I-mfa functions as a molecular switch to suppress the store dependence of TRPC1 PMID: 14530267
  4. These results suggest that the physical and functional interaction between Zic and I-mfa proteins can play a role in the vertebrate development. PMID: 15207726
Subcellular Location
Nucleus. Cytoplasm.
Protein Families
MDFI family
Database Links

HGNC: 6967

OMIM: 604971

KEGG: hsa:4188

STRING: 9606.ENSP00000230321

UniGene: Hs.520119

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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