MEF2D Antibody

Code CSB-PA613522LA01HU
Size US$166
Order now
Image
  • Western Blot
    Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate, Mouse heart tissue
    All lanes: MEF2D antibody at 2.7µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 56, 57, 51, 50 kDa
    Observed band size: 56 kDa

  • IHC image of CSB-PA613522LA01HU diluted at 1:400 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA613522LA01HU diluted at 1:400 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

The Latest Promotion Free Antibody trial simple
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MEF2D Polyclonal antibody
Uniprot No.
Target Names
MEF2D
Alternative Names
DKFZp686I1536 antibody; MADS box transcription factor 2 polypeptide D antibody; Mef2d antibody; MEF2D_HUMAN antibody; Myocyte enhancer factor 2D antibody; Myocyte specific enhancer factor 2, polypeptide D antibody; Myocyte specific enhancer factor 2D antibody; Myocyte-specific enhancer factor 2D antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Myocyte-specific enhancer factor 2D protein (299-509AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The MEF2D Antibody (Product code: CSB-PA613522LA01HU) is Non-conjugated. For MEF2D Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA613522LB01HU MEF2D Antibody, HRP conjugated ELISA
FITC CSB-PA613522LC01HU MEF2D Antibody, FITC conjugated
Biotin CSB-PA613522LD01HU MEF2D Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis.
Gene References into Functions
  1. Our study suggests that the MEF2D, PRDM16 and ASTN2 genes from GWAS are associated with migraine susceptibility, especially migraine without aura , among Chinese patients. It appears that there is no association with serotonin receptor related genes. PMID: 28058730
  2. In summary, we found that miR-1244 affected cisplatin-treated non-small cell lung cancer via MEF2D expression. PMID: 28498474
  3. MEF2d mRNA level is up-regulated in both sporadic and SOD1 + ALS patients. PMID: 26921792
  4. MEF2D might be a potential biomarker during chronic inflammation-lung cancer transition, predicting the risk of lung cancer among patients with chronic respiratory diseases. PMID: 28340574
  5. HIF-1alpha transactivates MEF2D expression by binding to the MEF2D gene promoter to induce angiogenesis in colorectal tumors. PMID: 28478181
  6. MEF2D directly regulated transcription of the epithelial-mesenchymal transition driver gene ZEB1 and facilitated histone acetylation at the ZEB1 promoter in colorectal cancer cells PMID: 27364559
  7. MEF2D-BCL9-positive patients had B-cell precursor immunophenotype and were characterized as being older in age, being resistant to chemotherapy, having very early relapse, and having leukemic blasts that mimic morphologically mature B-cell leukemia with markedly high expression of HDAC9. PMID: 27507882
  8. These results suggest that PPARgamma may exert its antiproliferative effects by negatively regulating the MEF2D in CM cells, which through upregulation of miR-122, and PPARgamma/miR-122/MEF2D signaling pathway may be a novel target for treatment of CM. PMID: 27109478
  9. MEF2D overexpression participated in the growth of lung cancers and its aberrant expression may result from the reduction of tumor suppressor miR-218. PMID: 26409449
  10. MEF2D is a direct target of miR-19. PMID: 26762410
  11. We found that in malignant glioma, there is an aberrantly high expression of MEF2D, which leads to poor prognosis of malignant glioma. The downregulation of MEF2D suppresses the proliferation of malignant glioma cell lines by inducing delay of S and G2/M phases of cell cycle and promoting apoptosis. PMID: 26234765
  12. MEF2D regulates IGF-1-induced proliferation and apoptosis in CM development, indicating IGF-1-MEF2D pathway may be a useful target for treatment. PMID: 26563368
  13. Pokemon was found to enhance the migration and invasion of hepatocellular carcinoma by increasing MEF2D expression PMID: 26797719
  14. miR-1244 and MEF2D form an autoregulatory loop contributing to the progression of lung carcinoma. PMID: 26355845
  15. MEF2D was also found to increase the transcription of Pokemon by binding myocyte enhancer factor 2 (MEF2) sites within its promoter region, that can promote Hepatocellular carcinoma invasion PMID: 26164003
  16. Cell cycle progression was also inhibited by MEF2D suppression. PMID: 25812649
  17. OA induced cell cycle arrest in lung cancer cells through miR-122/Cyclin G1/MEF2D pathway. This finding may contribute to the understanding of the molecular mechanism of OA's anti-tumor activity PMID: 25472877
  18. MEF2D suppression was shown to decrease the proliferation of osteosarcoma cells. PMID: 25814384
  19. Oxidation of survival factor MEF2D inhibits its function, underlies oxidative stress-induced neurotoxicity, and may be a part of the Parkinson disease pathogenic process. PMID: 24219011
  20. The oncogenic properties of rhabdomyosarcoma cells can be partially attributed to the loss of MEF2D expression. PMID: 24279793
  21. MEF2D-silencing abolished hepatocellular carcinoma tumorigenicity. PMID: 24390737
  22. The expression of MEF2D was higher in the higher clinical stage of nasopharyngeal carcinoma, but there was no correlation with survival rate. PMID: 22256741
  23. direct regulation of complex I by mitochondrial MEF2D underlies its neuroprotective effects, and dysregulation of this pathway may contribute to Parkinson disease PMID: 21393861
  24. data implicate MEF2D in human cancer and suggest that MEF2D/DAZAP1 and/or DAZAP1/MEF2D contribute to leukemogenesis by altering signaling pathways normally regulated by wild-type MEF2D and DAZAP1 PMID: 15744350
  25. histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications regulate MEF2 PMID: 16166628
  26. These results reveal an unexpected role for HDAC3 and suggest a novel pathway through which MEF2 activity is controlled in vivo. PMID: 17158926
  27. MEF2D levels were increased in the brains patients with Parkinson's disease PMID: 19119233

Show More

Hide All

Subcellular Location
Nucleus. Note=Translocated by HDAC4 to nuclear dots.
Protein Families
MEF2 family
Database Links

HGNC: 6997

OMIM: 600663

KEGG: hsa:4209

STRING: 9606.ENSP00000271555

UniGene: Hs.314327

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*