MESDC2 Antibody

Datasheet

Code	CSB-PA013708GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q14696

Target Names

MESD

Alternative Names

BOCA antibody; KIAA0081 antibody; LDLR chaperone MESD antibody; MESD antibody; MESD_HUMAN antibody; MESDC 2 antibody; mesdc2 antibody; Mesoderm development candidate 2 antibody; Mesoderm development protein antibody; Renal carcinoma antigen NY REN 61 antibody; Renal carcinoma antigen NY-REN-61 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human MESDC2

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.

Gene References into Functions

Mesd C-terminal region constitutes the major LRP5/6-binding domain, and that Mesd protein and its C-terminal region peptide have a potential therapeutic value in cancer PMID: 23469146
Results indicate that Mesd is a universal inhibitor of Wnt/LRP signaling on the cell surface. PMID: 21907199
Results provide evidence that MESD functions as a general LRP chaperone and suggest that the Mesd phenotype results from both signaling and endocytic defects resulting from misfolding of multiple LRP receptors. PMID: 21337463
Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/LRP6. PMID: 21397183
as a result of (12;15)(q13;q25)translocation, the SUMO/Sentrin-specific protease 1 gene (SENP1) on chromosome 12 and the embryonic polarity-related mesoderm development gene (MESDC2) on chromosome 15 are disrupted and fused PMID: 15917269
Mesd and LRP6 modulate Wnt signaling. PMID: 16989816

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Subcellular Location

Endoplasmic reticulum.

Protein Families

MESD family

Database Links

HGNC: 13520

OMIM: 607783

KEGG: hsa:23184

STRING: 9606.ENSP00000261758

UniGene: Hs.578450

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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