MINPP1 Antibody

Code CSB-PA039513
Size US$297
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  • Western blot analysis of extracts from 293 cells, using MINPP1 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MINPP1 Polyclonal antibody
Uniprot No.
Target Names
MINPP1
Alternative Names
3 antibody; 4 antibody; 5)-tetrakisphosphate 3-phosphatase antibody; 5)P(4) 3-phosphatase antibody; DKFZp564L2016 antibody; HIPER1 antibody; Inositol (1 antibody; inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase antibody; Ins(1 antibody; ins(1,3,4,5)P(4) 3-phosphatase antibody; MINP1_HUMAN antibody; Minpp1 antibody; MINPP2 antibody; MIPP antibody; Multiple inositol polyphosphate histidine phosphatase, 1 antibody; Multiple inositol polyphosphate phosphatase 1 antibody; multiple inositol polyphosphate phosphatase 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human MINPP1.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy.
Gene References into Functions
  1. Minpp1 exhibits characteristics of a stress responsive molecule during Endoplasmic reticulum stress-induced apoptosis PMID: 27038811
  2. By RNA knockdown, we identified secreted and lysosome targeted MINPP1 (multiple inositol-polyphosphate phosphatase 1), the mammalian 3-phytase, to be essentially involved both in extracellular and in lysosomal InsP6 dephosphorylation PMID: 23186306
Involvement in disease
Thyroid cancer, non-medullary, 2 (NMTC2)
Subcellular Location
Endoplasmic reticulum lumen.
Protein Families
Histidine acid phosphatase family, MINPP1 subfamily
Tissue Specificity
Widely expressed with highest levels in kidney, liver and placenta.
Database Links

HGNC: 7102

OMIM: 188470

KEGG: hsa:9562

STRING: 9606.ENSP00000361064

UniGene: Hs.121260

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