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MMP24 Antibody

Datasheet
Code CSB-PA062333
Size US$166
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  • Western Blotting(WB) - MMP24 Antibody
    Gel: 6%SDS-PAGE,Lysate: 40 μg,Lane 1-2: 293T cells, HepG2 cells,Primary antibody: CSB-PA062333(MMP24 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 40 seconds
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Product Details

Uniprot No.
Q9Y5R2
Target Names
MMP24
Alternative Names
Matrix metallopeptidase 24 (membrane inserted) antibody; Matrix metallopeptidase 24 antibody; Membrane type 5 matrix metalloproteinase antibody; Membrane type matrix metalloproteinase 5 antibody; Membrane-type matrix metalloproteinase 5 antibody; Membrane-type-5 matrix metalloproteinase antibody; MMP 24 antibody; MMP 25 antibody; MMP-24 antibody; Mmp24 antibody; MMP24_HUMAN antibody; MMP25 antibody; MT MMP5 antibody; MT-MMP 5 antibody; MT5 MMP antibody; MT5-MMP antibody; MT5MMP antibody; MTMMP5 antibody; Processed matrix metalloproteinase-24 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide of Human MMP24
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
WB 1:200-1:1000
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Related Products

MMP24 Antibodies

MMP24 Proteins

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Target Background

Function
Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin.
Gene References into Functions
  1. MMP24 overexpression is associated with lung cancer metastasis. PMID: 27869830
  2. Polymorphisms in MAP3K3, MMP24 and IGF1R are associated with greater height and act additively on height in children of an admixed population. PMID: 26304632
  3. In absolute mRNA levels, significant differences were found in expression of MMP2, MMP24, and MMP25 in gastric carcinoma compared with superficial gastritis. PMID: 24669030
  4. MMP-24 gene silencing by RNAi can suppress the invasiveness of ovarian cancer SKOV(3) cells in vitro. PMID: 19403421
  5. down-regulation of most MT-MMPs is typical for prostate carcinoma; seems to occur mainly in epithelial cells PMID: 12661033
  6. MT5-MMP retrieval to the plasma membrane is regulated by Mint-3 by binding to its carboxyl end motif EWV PMID: 14990567
  7. MT5-MMP is expressed in normal human endometrium and there is enhanced exprestion in endometrium from patients with entometriosis with strongest signal in epithelial cells. PMID: 17952761
  8. These results suggest more than one human MT5-MMP transcript may exist in the central nervous system. PMID: 18062926

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Subcellular Location
[Matrix metalloproteinase-24]: Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.; [Processed matrix metalloproteinase-24]: Secreted, extracellular space, extracellular matrix.
Protein Families
Peptidase M10A family
Tissue Specificity
Predominantly expressed in brain, kidney, pancreas and lung. Overexpressed in a series of brain tumors, including astrocytomas and glioblastomas.
Database Links

HGNC: 7172

OMIM: 604871

KEGG: hsa:10893

STRING: 9606.ENSP00000246186

UniGene: Hs.715494

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