MRPL41 Antibody

Datasheet

Code	CSB-PA003297
Size	US$119
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Image	Western Blot analysis of HepG2 cells using MRP-L41 Polyclonal Antibody
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Product Details
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Target Background

Product Details

Uniprot No.

Q8IXM3

Target Names

MRPL41

Alternative Names

39S ribosomal protein L27 homolog antibody; 39S ribosomal protein L41 antibody; 39S ribosomal protein L41 mitochondrial antibody; Bcl-2-interacting mitochondrial ribosomal protein L41 antibody; BMRP antibody; Cell proliferation-inducing gene 3 protein antibody; L41mt antibody; mitochondrial antibody; Mitochondrial ribosomal protein L41 antibody; MRP L27 antibody; MRP-L27 homolog antibody; MRP-L41 antibody; MRPL27 antibody; mRpL41 antibody; PIG3 antibody; Proliferation inducing gene 3 antibody; RM41_HUMAN antibody; RPML27 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human MRP-L41.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

WB, IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:40000

Protocols

Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.

Gene References into Functions

Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer. PMID: 24160266
Apoptosis-inducing ability of wild-type BMRP is blocked by Bcl-2 through several mechanisms. PMID: 22711503
region of BMRP required for the interaction with Bcl-2 is very relevant for the cell death-inducing activity of the protein PMID: 21253851
BMRP is a mitochondrial ribosomal protein involved in the regulation of cell death by apoptosis, probably affecting pathways mediated by Bcl-2 and caspases. PMID: 15547950
mitochondrial ribosomal protein L41 (MRPL41) is localized in the mitochondria, stabilizes the p53 protein, and enhances its translocation to the mitochondria, thereby inducing apoptosis. PMID: 16024796
Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21(WAF1/CIP1) and p27(Kip1) levels under the growth inhibitory conditions. PMID: 16256947

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Subcellular Location

Mitochondrion.

Protein Families

Mitochondrion-specific ribosomal protein mL41 family

Tissue Specificity

Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).

Database Links

HGNC: 14492

OMIM: 611846

KEGG: hsa:64975

STRING: 9606.ENSP00000360498

UniGene: Hs.44017

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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