NKIRAS1 Antibody

Code CSB-PA885767LA01HU
Size US$166
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  • Western blot
    All lanes: NKIRAS1 antibody at 7µg/ml + HepG2 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 22 kDa
    Observed band size: 22 kDa

  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA885767LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA885767LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NKIRAS1 Polyclonal antibody
Uniprot No.
Target Names
NKIRAS1
Alternative Names
2400004O09Rik antibody; I kappa B interacting Ras like protein 1 antibody; I-kappa-B-interacting Ras-like protein 1 antibody; Kappa B Ras 1 antibody; Kappa B Ras protein 1 antibody; Kappa B-Ras protein 1 antibody; KappaB Ras1 antibody; KappaB-Ras1 antibody; KBRAS 1 antibody; KBRAS1 antibody; KBRS1_HUMAN antibody; NF kappa B inhibitor interacting Ras like protein 1 antibody; NF-kappa-B inhibitor-interacting Ras-like protein 1 antibody; NFKB inhibitor interacting Ras like 1 antibody; NFKB inhibitor interacting Ras like protein 1 antibody; NKIRAS 1 antibody; nkiras1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human NF-kappa-B inhibitor-interacting Ras-like protein 1 protein (1-192AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The NKIRAS1 Antibody (Product code: CSB-PA885767LA01HU) is Non-conjugated. For NKIRAS1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA885767LB01HU NKIRAS1 Antibody, HRP conjugated ELISA
FITC CSB-PA885767LC01HU NKIRAS1 Antibody, FITC conjugated
Biotin CSB-PA885767LD01HU NKIRAS1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
Gene References into Functions
  1. It was demonstrated that elevated levels of mRNA for NKIRAS1 was significantly associated both with loss of methylation in NKIRAS1 CpG-islands and methylation in a number of miRNA genes. PMID: 25869366
  2. Significant correlation was found between alterations of methylation status of miR-34b/c, miR-193a and the expression level of NKIRAS1 target gene in the primary lung tumors. PMID: 23156677
  3. Low kappaB-Ras1 expression is associated with gliomas. PMID: 21302000
  4. It was shown the decreased expression level of NKIRAS1 in Renal cell carcinoma PMID: 20693965
Subcellular Location
Cytoplasm.
Protein Families
Small GTPase superfamily, Ras family, KappaB-Ras subfamily
Tissue Specificity
Widely expressed.
Database Links

HGNC: 17899

OMIM: 604496

KEGG: hsa:28512

STRING: 9606.ENSP00000373411

UniGene: Hs.173202

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