OPN4 Antibody

1. Valuable insight into the structure-function relationships of human melanopsin, including several key functional residues of the melanopsin protein. The identification of melanopsin variants with significantly altered function may serve to detect individuals with disrupted melanopsin-based light perception, and potentially highlight those at increased risk of sleep disturbance, circadian dysfunction, and visual disorders. PMID: 29700553
2. The wide distribution of OPN4 in central areas of the human brain evokes a question whether ambient light has important straight targets in the human brain outside the retinohypothalamic tract. PMID: 27690288
3. Trait-like individual differences in the melanopsin phototransduction circuitry contribute to individual differences in sleep timing. Blue light-sensitive young individuals are more prone to delayed sleep. PMID: 27091519
4. The light-induced FOS response in melanopsin expressing HEK-293 cells is correlated with melanopsin quantity and dependent on light duration and irradiance. PMID: 24909488
5. By broadening the tuning of intrinsically photosensitive retinal ganglion cells, melanopsin tristability produces signal integration. PMID: 25741728
6. The response of the human pupil to the separate stimulation of the cones and melanopsin at a range of temporal frequencies under photopic conditions, was measured. PMID: 25313040
7. Studied OPN4*Ile394Thr gene polymorphism in association with sleep/wake timing. PMID: 24887407
8. The results of this study showed that the post illumination pupil response varied on the basis of OPN4 I394T genotype among individuals with seasonal affective disorder. PMID: 23809464
9. Studied the association between melanopsin gene polymorphism and pupillary light reflex under diverse photic conditions, including different intensities and wavelengths. PMID: 24119231
10. A comparison of melanopsin with the mechanisms documented for vertebrate (bovine) and invertebrate (squid) visual photoreceptors shows that such a mechanism is not affected by the diversity of the three chromophore cavities. PMID: 24449866
11. Significant interaction between the genotype of I394T (TT versus TC+CC) and luminance levels was found in pupil size. PMID: 23555953
12. An action spectrum for the calcium response in cells expressing human melanopsin had the predicted form for an opsin : vitamin A1 pigment and peaked at 479 nm. The G-protein selectivity and spectral sensitivity of human melanopsin is similar to that previously described for rodents. PMID: 23554393
13. the results indicate that ectopic expression of human OPN4 in orexin neurons enables long-lasting activation of orexin neurons by blue light to control sleep/wakefulness of the mice. PMID: 22868039
14. These results suggest that the P10L TT genotype of melanopsin interacts with daylength to predispose individuals to vary in sleep onset and chronotype as a function of daylength. PMID: 22881342
15. The relative contribution of melanopsin and visual photoreceptors are assessed by comparing pupillary light reflex responses in a totally visually blind patient with normally sighted individuals. PMID: 23055493
16. Melanopsin and mechanisms of non-visual ocular photoreception PMID: 22074930
17. The recent advances in the emerging roles of melanopsin and intrinsically photosensitive retinal ganglion cells, are reviewed. PMID: 20810319
18. melanopsin acts as a sensory photopigment, coupled to a native ion channel via a G-protein signalling cascade, to drive physiological light detection PMID: 15674244
19. an anatomically distinct population of 'giant', melanopsin-expressing ganglion cells in the primate retina that, in addition to being intrinsically photosensitive, are strongly activated by rods and cones PMID: 15716953
20. Regulation of melanopsin expression [review] PMID: 16687290
21. HEK293 cells stably expressing melanopsin have proven to be a useful tool to study melanopsin-initiated signaling. PMID: 16961436
22. Data show that Seasonal Affective Disorder participants have a higher frequency of the melanopsin (OPN4) homozygous minor genotype (T/T) for the missense variant rs2675703 (P10L) than controls, compared to the combined frequencies of C/C and C/T. PMID: 18804284

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HGNC: 14449

OMIM: 606665

KEGG: hsa:94233

STRING: 9606.ENSP00000361141

UniGene: Hs.283922