ORC6 Antibody

Datasheet

Code	CSB-PA893418ESR2HU
Size	US$166
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Image	Western blot All lanes: ORC6 antibody at 16μg/ml Lane 1: Mouse spleen tissue Lane 2: MCF-7 whole cell lysate Lane 3: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 28 kDa Observed band size: 28 kDa Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA893418ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ORC6 Polyclonal antibody

Uniprot No.

Q9Y5N6

Target Names

ORC6

Alternative Names

ORC 6 antibody; Orc6 antibody; ORC6_HUMAN antibody; ORC6L antibody; Origin recognition complex subunit 6 antibody; origin recognition complex subunit 6 homolog like antibody; origin recognition complex subunit 6 homolog like (yeast) antibody; origin recognition complex subunit 6 like (yeast) antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Origin recognition complex subunit 6 protein (1-252AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.

Gene References into Functions

The 11-year-old boy with Meier-Gorlin syndrome (MGS) has a homozygous mutation in origin recognition complex, subunit 6 (ORC6) gene mapped to chromosome 16, and his father with heterozygote carrier of ORC6 gene. PMID: 28186598
The present report expands the clinical phenotype associated with ORC6 mutations to include severely abnormal embryological development suggesting a possible genotype-phenotype correlation. PMID: 25691413
our results suggest that Meier-Gorlin syndrome mutations in Orc6 impair the formation of ORC hexamers, interfering with appropriate ORC functions PMID: 24137536
findings show that Orc6 not only interacts with Orc1-Orc5 but also with the initiation factor Cdc6, and that Orc6 functions at different stages of the replication initiation process. PMID: 21461783
Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB. PMID: 21502537
results implicate Orc6 as an essential gene that coordinates chromosome replication and segregation with cytokinesis PMID: 12169736
Study using HCT116 haplo-insufficient cells and Orc2 hypomorphic cells demonstrates that the binding of human Ku to replication origins precedes that of Orc-3, -4, and -6 subunit binding. PMID: 15910003
Orc6 has a role in sensitizing human colon cancer cells to 5-fluorouracil and cisplatin PMID: 19112505
In a cross-species complementation experiment, the expression of human Orc6 in Drosophila Orc6 mutant cells rescued DNA replication, suggesting that this function of the protein is conserved among metazoans. PMID: 19541634
Functional studies of the Drosophila homolog PMID: 11593009
Functional studies of the yeast homolog PMID: 8266075

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Involvement in disease

Meier-Gorlin syndrome 3 (MGORS3)

Subcellular Location

Nucleus.

Protein Families

ORC6 family

Database Links

HGNC: 17151

OMIM: 607213

KEGG: hsa:23594

STRING: 9606.ENSP00000219097

UniGene: Hs.49760

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Related pathways

Cell cycle

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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