PIM3 Antibody

1. show that PIM1 contributes to melanoma cell proliferation and tumor growth in vivo; however, the presence of PIM2 and PIM3 could also influence the outcome. PMID: 27448973
2. These results demonstrate the involvement of PIM kinases in LIF-induced regulation in different trophoblastic cell lines which may indicate similar functions in primary cells. PMID: 28729093
3. PIM kinases in classical Hodgkin lymphoma exhibit pleiotropic effects, orchestrating tumor immune escape and supporting Reed-Sternberg cell survival. PMID: 28698206
4. Our study suggests that up-regulation of Pim-3 successfully accelerated Chronic Obstructive Pulmonary Disease development, and aggravated lung damage PMID: 28214201
5. High PIM3 expression is associated with osteosarcoma. PMID: 27826617
6. The expression status of Pim-3 mRNA was significantly associated with pathological parameters such as pre-surgery prostate specific antigen, Gleason score, pathological stage, and lymphoid metastasis. PMID: 27826135
7. Pim-3 expression was inversely correlated with that of miR-377. PMID: 27638830
8. SSRP1/Ets-1/Pim-3 signalling is tightly associated with the proliferation, apoptosis, autophagy, invasion and clonogenicity of nasopharyngeal carcinoma cells, and blockage of this signalling facilitates chemosensitivity of the cells to docetaxel. PMID: 27525970
9. Pim-3 expression showed a positive correlation with tumor cell differentiation. PMID: 26768612
10. Pim-3 has a role in human pancreatic cancer cell survival against radiation PMID: 27016481
11. A high percentage of urothelial carcinomas express Pim kinases. Pim expression differs in NILG, NIHG, and IHG lesions. PMID: 26551340
12. MicroRNA506 participates in pancreatic cancer pathogenesis by targeting PIM3 PMID: 26238203
13. Pim-3 kinase enhances growth and metastatic properties of prostate cancer xenografts. PC-3 prostate cancer cells overexpressing either Pim-1 or Pim-3 kinases form larger xenograft tumors than the parental PC-3 cells. PMID: 26075720
14. Knockdown of Pim-3 by specific shRNA slowed decreased proliferation, induced cell cycle arrest in the G0/G1 phase, and increased apoptosis in glioblastoma cells. PMID: 25817345
15. PIM3 expression is higher in ovarian cancer than in normal ovarian tissue. Upregulation of PIM3 promotes proliferation and migration of ovarian cancer cells. PMID: 25921139
16. Data demonstrate the role of PIM kinases in driving myeloid leukemia, and as candidate molecules for therapy against human malignancies. PMID: 25238262
17. we constructed a dual-function small hairpin RNA (shRNA) vector containing an shRNA targeting Pim-3 and a TLR7-stimulating ssRNA. PMID: 24723452
18. Blocking the activities of PIM kinases(PIM1, PIM2 and PIM3) could prevent pancreatic cancer development. PIM kinases(PIM1, PIM2 and PIM3) may be a novel target for cancer therapy PMID: 24799066
19. cancer development and in promoting tumor neovascularization and subsequent tumor growth. Targeting Pim-3 may play a dual role in halting tumor progression, by promoting tumor cell death and blocking angiogenesis PMID: 24789328
20. Our study indicates that the expression of Pim kinases is physiologically related to DNA-PKcs and ATM in ECs. PMID: 22282239
21. observations indicate that TCTP enhances Pim-3 stability to simultaneously promote and prevent cell-cycle progression and apoptosis, respectively PMID: 24165482
22. the existence of different patterns of expression of Pim-3, c-Myc, and p-p27 and their clinicopathologic correlations in adenocarcinomas of the gastric cardia and the distal stomach. PMID: 24488669
23. Pim-1 and Pim-3 play overlapping but non-identical roles as it relates to gemcitabine sensitivity of pancreatic cancer cells and Pim-3 is upregulated in pancreatic ductal carcinoma. PMID: 23760491
24. Pim-3 can promote pancreatic tumor growth and angiogenesis by stimulating the VEGF pathway. PMID: 23845873
25. PIM kinases promote the production of IFNgamma, the hallmark cytokine produced by Th1 cells. PMID: 23209281
26. Pim protein kinase-3 is regulated by TNF-alpha and promotes endothelial cell sprouting. PMID: 21870113
27. Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomas. PMID: 21646687
28. Ginsenoside Rg3 decreased both Pim-3 and pBad expressions in a dose-dependent manner in PANC-1 cells. PMID: 19624871
29. A cell-based test system useful for rapid and inexpensive pre-screening of compounds capable of preventing Pim-mediated phosphorylation is discussed. PMID: 20939820
30. Pim-3 has an important role in modulating c-Myc and PGC-1alpha protein levels and cell growth PMID: 21187426
31. Pim-3 alone cannot cause, but can accelerate HCC development. PMID: 20101231
32. Aberrnntly expressed Pim-3 can cause autonomous cell proliferation or prevent apoptosis in hepatoma cell lines. PMID: 15540201
33. Pim kinases promote cell cycle progression and tumorigenesis by down-regulating p27(Kip1) expression at both transcriptional and posttranslational levels. PMID: 18593906
34. Ets-1 can induce aberrant Pim-3 expression and subsequently prevent apoptosis in human pancreatic cancer cells. PMID: 19154409
35. expression of Pim-1 & Pim-3 is induced in response reactivation in KSHV-infected cells; they are required for KSHV reactivation under these conditions; data indicate Pim-1 & Pim-3 contribute to viral reactivation by phosphorylating the KSHV LANA PMID: 19266083

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HGNC: 19310

OMIM: 610580

KEGG: hsa:415116

STRING: 9606.ENSP00000353824

UniGene: Hs.530381