PPFIA1 Antibody

1. The results indicate that liprin-alpha1, LL5 and ERC1 define a novel dynamic membrane-less compartment that regulates matrix degradation by affecting invadosome motility. PMID: 29348417
2. This study shows that PPFIA1 is required for FN polymerization-dependent vascular morphogenesis, both in vitro and in the developing zebrafish embryo. PMID: 27876801
3. Based on these findings, we infer that high PPFIA1 expression might be an independent prognostic indicator of increased metastatic relapse risk in patients with estrogen receptor+/N- breast cancer, but not in estrogen receptor+/N+ or estrogen receptor- patients. PMID: 28720060
4. The human tumor cell line MDA-MB-231 expresses liprin-alpha 1 and is able to promote the formation of metastasis in mice. PMID: 26663347
5. results suggested that PPFIA1 functioned with PP2A to promote the dephosphorylation of Kif7, triggering Kif7 localization to the tips of primary cilia and promoting Gli transcriptional activity. PMID: 25492966
6. Liprin-alpha1, ERC1a and LL5 also define new highly polarized and dynamic cytoplasmic structures uniquely localized near the protruding cell edge PMID: 24982445
7. PPFIA1 was frequently co-amplified with the Cyclin D1 gene in oral carcinomas and could present a biomarker as well as a novel target for specific gene therapy. PMID: 23453270
8. PPFIA1 as a potential functional candidate acute lung injury risk gene PMID: 22295056
9. The results of this study finding suggested that a model by which the self-assembly of SYD-2/Liprin-alpha proteins mediated by the coiled-coil LH1 domain is one of the key steps to the accumulation of presynaptic components at nascent synaptic junctions PMID: 22072677
10. These results suggest that an increased expression of Liprin-alpha1 in the brain may be associated with human Intractable epilepsy . PMID: 21157931
11. Data show that increased levels of liprin-alpha1 affected the localization of inactive, low-affinity integrins, while increasing the average size of beta1 integrin-positive focal adhesions. PMID: 20096687
12. Amplification of both PPFIA1 and CCND1 were significantly associated with high-grade breast cancer phenotype but were unrelated to tumor stage or nodal stage PMID: 19787783
13. the interaction between ERC2 and liprin-alpha may be involved in the presynaptic localization of liprin-alpha and the molecular organization of presynaptic active zones PMID: 12923177
14. liprin binds to ATP-agarose, challenged by free ATP, not by free GTP. Liprin LH region mutations inhibit liprin phosphorylation stabilized association of liprin with ATP-agarose. Suggests that liprin autophosphorylation regulates its association with LAR. PMID: 16313174
15. regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII. PMID: 17419996
16. Amplification and overexpression of PPFIA1, a putative 11q13 invasion suppressor gene, is associated with head and neck squamous cell carcinoma PMID: 18196592
17. Liprin is an essential regulator of cell motility that contributes to the effectiveness of cell-edge protrusion. PMID: 19690048

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HGNC: 9245

OMIM: 611054

KEGG: hsa:8500

STRING: 9606.ENSP00000253925

UniGene: Hs.530749