PRDX5 Antibody

Code CSB-PA018658ESR1HU
Size US$166
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  • Western blot
    All lanes: PRDX5 antibody at 4µg/ml
    Lane 1: Mouse brain tissue
    Lane 2: Hela whole cell lysate
    Lane 3: 293T whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 23, 18, 13 kDa
    Observed band size: 23 kDa

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018658ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human epityphlon tissue using CSB-PA018658ESR1HU at dilution of 1:100

  • Immunofluorescent analysis of PC-3 cells using CSB-PA018658ESR1HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PRDX5 Polyclonal antibody
Uniprot No.
Target Names
PRDX5
Alternative Names
ACR1 antibody; Alu co repressor 1 antibody; Alu corepressor 1 antibody; Antioxidant enzyme B166 antibody; AOEB166 antibody; B166 antibody; epididymis secretory protein Li 55 antibody; HEL-S-55 antibody; Liver tissue 2D-page spot 71B antibody; mitochondrial antibody; Peroxiredoxin 5; mitochondrial antibody; Peroxiredoxin V antibody; Peroxiredoxin-5 antibody; Peroxisomal antioxidant enzyme antibody; PLP antibody; PMP20 antibody; PRDX 5 antibody; PRDX5 antibody; PRDX5_HUMAN antibody; PRDX6 antibody; Prx-V antibody; PRXV antibody; SBBI10 antibody; Thioredoxin peroxidase PMP20 antibody; Thioredoxin reductase antibody; TPx type VI antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Peroxiredoxin-5, mitochondrial protein (53-214AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
Gene References into Functions
  1. High PRX5 expression is associated with gastric cancer. PMID: 28535004
  2. Results found that Prx5 was increased in the cellular model of Alzheimer's disease (AD) and, identify a role for Prx5 as an upregulator of Cdk5 activation via reactive oxygen species-mediated Ca2+-mediated calpain activation. PMID: 28358580
  3. The PRX5 can be used as a predictive biomarker and serves as a putative therapeutic target for the development of clinical treatments for human CRC. PMID: 28431931
  4. peroxisomal PRDX5 protects oligodendrocytes against peroxisomal and mitochondrial oxidative stress. PMID: 25772011
  5. show here how the ligand-observed saturation transfer difference (STD) experiment and the PRDX5 protein-observed 15N-HSQC experiment, two popular NMR screening experiments, can be used to compare the binding modes of analogous fragments PMID: 25025339
  6. PRX5 is either consumed or its production is impaired in severe stroke PMID: 24385276
  7. This study demonistrated that overexpression of mitochondrial PRDX5 protects SH-SY5Y cells against the ROS/RNS-dependent neuronal death induced by MPP+. PMID: 23216451
  8. The promoter region critical for Prx5 gene regulation to which the novel negative transcription regulator, GATA1 binds in human breast cancer cell lines. PMID: 22020876
  9. basal expression of the human PRDX5 gene is regulated by GABP PMID: 20937353
  10. analysis of fragment molecules that bind the human peroxiredoxin 5 active site PMID: 20305821
  11. Glutaredoxin-dependent peroxiredoxin from poplar: protein-protein interaction and catalytic mechanism PMID: 11832487
  12. the expression of peroxiredoxin 5 is upregulated in osteoarthritis PMID: 12417342
  13. multiple subcellular targeting of peroxiredoxin 5 in mammalian cells can be implicated in antioxidant protective mechanisms under nonpathological conditions PMID: 14732291
  14. Transfection of PRXVI protects immortalized human WI-38 and murine NIH3T3 fibroblasts against cytotoxic doses of tert-butylhydroperoxide and H2O2 PMID: 14741336
  15. new crystal form of human peroxiredoxin 5 is described at 2.0 A resolution; under initial reducing conditions, one chain remains oxidized and forms an homodimer with a symmetry-related one through intermolecular disulfide bonds between Cys47 and Cys151 PMID: 15046979
  16. plays a protective role in human tendon cells against oxidative stress by reducing apoptosis and maintaining collagen synthesis PMID: 15276323
  17. Human peroxiredoxin 5 is also a peroxynitrite reductase. PMID: 15280035
  18. nuclear PrxV associates with coilin-containing bodies suggesting possible interaction of this protein with transcription complexes PMID: 15304327
  19. The level of expression is directly correlated with the functional status of epithelial cells, being higher in multinodular goiters, and even more pronounced in hyperthyroid tissues, such as Graves' disease. PMID: 15785239
  20. mitochondrial peroxiredoxin 5 may play an important role in mitochondrial genome stability PMID: 15848167
  21. these findings suggest that PrxV is a multifunctional protein, which is essential for protection against apoptosis induced by anticancer drugs. PMID: 16781710
  22. Together, these results suggest that constitutively expressed PRDX5 gene plays an important role in protecting the genome against oxidation and may also be involved in the control of transcription of noncoding DNA. PMID: 16817890
  23. expression in white matter from normal human brain and MS patients PMID: 17623739
  24. we present new alternative splicing variants encoded specifically by human PRDX5 gene. The characterization of human PRDX5 gene revealed complexity of its regulation & high variability of sequences that might be associated with pathological situations. PMID: 17628720
  25. kinetic analysis of human peroxiredoxin 5 PMID: 17892856
  26. Peroxiredoxin V (PRXV) is an important antioxidant protein of lung epithelial cells. Its expression in the human lung increases in inflammation. PMID: 18219526
  27. report here three crystal forms in which this intramolecular disulfide bond is indeed observed. The structures are characterized by the expected local unfolding of the peroxidatic loop, but also by the unfolding of the resolving loop PMID: 18489898
  28. Ets regulates PRDX5 expression through their interaction with HGMB1 protein. PMID: 19016754
  29. crystal structure at 1.5 angstrom resolution PMID: 11518528

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Subcellular Location
[Isoform Mitochondrial]: Mitochondrion.; [Isoform Cytoplasmic+peroxisomal]: Cytoplasm. Peroxisome matrix.
Protein Families
Peroxiredoxin family, Prx5 subfamily
Tissue Specificity
Widely expressed.
Database Links

HGNC: 9355

OMIM: 606583

KEGG: hsa:25824

STRING: 9606.ENSP00000265462

UniGene: Hs.502823

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