Phospho-NFKBIE (Ser22) Antibody

Code CSB-PA974723
Size US$360
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Image
  • Western blot analysis of extracts from 293 cells untreated or treated with TNF using IkB-e(Phospho-Ser22) Antibody.
  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IkB-e(Phospho-Ser22) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NFKBIE Polyclonal antibody
Uniprot No.
Target Names
NFKBIE
Alternative Names
I kappa B epsilon antibody; I-kappa-B-epsilon antibody; IkappaBepsilon antibody; IkB E antibody; IkB-E antibody; IkB-epsilon antibody; IKBE antibody; IKBE_HUMAN antibody; MGC72568 antibody; NF kappa B inhibitor epsilon antibody; NF kappa BIE antibody; NF-kappa-B inhibitor epsilon antibody; NF-kappa-BIE antibody; NFkappa BIE antibody; NFkappaB inhibitor epsilon antibody; NFKBIE antibody; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor epsilon antibody; OTTHUMP00000016522 antibody; Slc35b2 antibody; solute carrier family 35; member B2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Peptide sequence around phosphorylation site of serine 22 (I-E-S(p)-L-R) derived from Human IkB-e.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:1000
IHC 1:50-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.
Gene References into Functions
  1. identify NFKBIE aberrations as a common genetic event across B-cell malignancies and highlight NFKBIE deletions as a novel poor-prognostic marker in PMBL. PMID: 27670424
  2. We suggest that the impairment of NFKBIE gene function can reduce the uptake of methotrexate into cells, suggesting that the gene is an important factor for rheumatoid arthritis outcome PMID: 26587663
  3. A NFKBIE polymorphism was associated with increased risk of pneumococcal meningitis. PMID: 26870821
  4. results show that Gal-1 acts by inhibiting the stimulation of the LPS-induced IkappaBzeta expression, an NF-kappaB regulator involved in IL-6 gene transcription. PMID: 26226212
  5. Newly identified alterations included recurrent promoter mutations of NFKBIE, encoding NF-kappaB inhibitor varepsilon (IkappaBvarepsilon), in 14.5% of samples of desmoplastic melanoma PMID: 26343386
  6. Vitamin C forestalls cigarette smoke induced NF-kappaB activation in alveolar epithelial cells. PMID: 23615073
  7. we identified two gene loci associated with rheumatoid arthritis susceptibility- NFKBIE and RTKN2 PMID: 23028356
  8. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon PMID: 16769727
  9. An NFKBIE SNP associated with susceptibility to pneumococcal disease but not pneumococcal empyema. PMID: 17463416
  10. Expression levels of GGT1 and possibly NFKBIE might be useful as biomarkers of genetic susceptibility to arsenite. PMID: 17976673
  11. Genomic mutation of the NFKBIE gene in primary Hodgkin/ Reed Sternberg cells PMID: 14595753

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Subcellular Location
Cytoplasm.
Protein Families
NF-kappa-B inhibitor family
Tissue Specificity
Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages.
Database Links

HGNC: 7799

OMIM: 604548

KEGG: hsa:4794

STRING: 9606.ENSP00000275015

UniGene: Hs.458276

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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