Phospho-RRN3 (S649) Antibody

1. These data support a model in which activated Akt enhances rRNA synthesis both by preventing TIF-IA degradation and phosphorylating CK2alpha, which in turn phosphorylates TIF-IA. PMID: 24297901
2. DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription PMID: 23393135
3. reveals the molecular basis of Rrn3-regulated Pol I initiation and cell growth PMID: 21940764
4. Data show that nutrient starvation, density arrest and protein synthesis inhibitors inactivate transcription initiation factor-IA and impair its association with RNA polymerase I. PMID: 12393749
5. ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. PMID: 12620228
6. Phosphorylation of S44 activates and S199 inactivates TIF-IA. PMID: 15004009
7. The definition of the Alu element within the TIF-IA gene as an exon is restricted to certain types of cancers; the element is not exonized in normal human cells. PMID: 18047649
8. CK2 phosphorylates the transcription initiation factor TIF-IA at serines 170 and 172 (Ser170/172), and this phosphorylation triggers the release of TIF-IA from Pol I after transcription initiation. PMID: 18559419

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HGNC: 30346

OMIM: 605121

KEGG: hsa:54700

STRING: 9606.ENSP00000198767

UniGene: Hs.460078