SCN2B Antibody

Code CSB-PA003361
Size US$100
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  • Western Blot analysis of 293 cells using Na+ CP type IIβ Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
SCN2B
Alternative Names
SCN2B; UNQ326/PRO386; Sodium channel subunit beta-2
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human Na+ CP type IIβ.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.
Gene References into Functions
  1. Findings add to the understanding of beta2 role in Nav 1.5 trafficking and localisation, which must influence cell excitability and electrical coupling in the heart. PMID: 28597987
  2. The authors identified a flexible loop formed by (72)Cys and (75)Cys, a unique feature among the four beta-subunit isoforms. PMID: 26894959
  3. With increased beta-2 expression, prostate cancer cells display a trend of enhanced association with nerve axons. PMID: 24892658
  4. SCN2B is a new candidate gene associated with Brugada syndrome. PMID: 23559163
  5. beta2 is a PS/gamma-secretase substrate, gamma-secretase mediated cleavage of beta2-C-terminal fragment is required for cell-cell adhesion and migration of beta2-expressing cells PMID: 15833746

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Involvement in disease
Atrial fibrillation, familial, 14 (ATFB14)
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Sodium channel auxiliary subunit SCN2B (TC 8.A.17) family
Tissue Specificity
Brain specific.
Database Links

HGNC: 10589

OMIM: 601327

KEGG: hsa:6327

STRING: 9606.ENSP00000278947

UniGene: Hs.129783

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