SEMA3B Antibody

Code CSB-PA622646ESR2HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA622646ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SEMA3B Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
SEM3B_HUMAN antibody; Sema A(V) antibody; Sema V antibody; Sema3b antibody; Semaphorin V antibody; Semaphorin-3B antibody; Semaphorin-V antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Semaphorin-3B protein (570-749AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
Gene References into Functions
  1. Advanced peri-implantitis lesions showed higher levels of gene expression for Sem3A and Sem4D and lower levels of Sem4A in comparison to tissues obtained from a healthy dental implant. PMID: 29763494
  2. data provide new insights into the role of SEMA3B in mammary gland and provides a new branch of GATA3 signaling that is pivotal for inhibition of breast cancer progression and metastasis PMID: 28581515
  3. By upregulating p53 and p21 expression and inhibiting Akt (Ser473) phosphorylation, SEMA3B could induce cell cycle arrest at G1/S phase. PMID: 27349960
  4. As the clinical pathological glioma grade increased, SEMA3B expression decreased. PMID: 27050958
  5. Maternal SEMA 3B level increased in preeclampsia before the onset of manifestations, indicating that SEMA 3B plays a role in the pathogenesis of preeclampsia PMID: 26828533
  6. Aberrant expression and methylation of SEMA3B could be suggested as markers of lung and renal cancer progression. PMID: 25961819
  7. although plexin-A4 overexpression restored Sema3A signaling in plexin-A1-silenced cells, it failed to restore Sema3B signaling in plexin-A2-silenced cells. PMID: 25335892
  8. SEMA3B mRNA and protein is not altered in severe early onset preeclamptic placentas. PMID: 25454475
  9. CpG methylation of SEMA3B epigenetically regulates SEMA3B expression during development of gastric cancer. PMID: 24402303
  10. The transcriptional activity of RHOA, SEMA3B, and CKAP2 genes was assessed in blood samples of leukaemia patients and healthy donors. PMID: 24280143
  11. Three candidate tumor-suppressor genes, SEMA3B, AXUD1 and GNAT1 may be involved in oral squamous cell carcinoma. PMID: 23292452
  12. Loss of Sema3B expression is associated with biochemical recurrence of patients with low- and intermediate-risk prostate cancer. PMID: 23906303
  13. semaphorin-3B and semaphorin-3F have roles in ovarian cancer PMID: 20124444
  14. that methylation of promoter CpG-island contributed into inactivation of SEMA3B gene-suppressor in RCC. PMID: 20088387
  15. Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line. PMID: 11809707
  16. SEMA3B gene alterations may play a important role in the malignant transformation of NSCLC via a two-hit mechanism, including epigenetic changes and allelic loss, for tumor suppressor gene inactivation. PMID: 12810670
  17. Heterozygous or homozygous variant genotype confers a >40% reduced relative risk of lung cancer in Latino Americans controlling for other lung cancer risk factors. PMID: 15831529
  18. Higher level of SEMA3B expression was found in differentiated tumors with favorable histopathology (n = 19) than in tumors with unfavorable histology. PMID: 17452250
  19. A putative role for SEMA3B as an osteoblast protein that regulates bone mass and skeletal homeostasis. PMID: 18356290
  20. SEMA3B exerts unexpected functions in cancer progression by fostering a prometastatic environment through elevated IL-8 secretion. PMID: 18458115
  21. Repulsion of human umbilical vascular endothelial cells by sema3B-m was mediated primarily by the neuropilin-1 receptor but sema3B-m was also able to transduce signals via neuropilin-2 PMID: 18757406
  22. SEMA3B is a potential tumor suppressor that induces apoptosis in SEMA3B-inactivated tumor cells through the Np-1 receptor by inactivating the Akt signaling pathway. PMID: 18922901
  23. IGFBP-6 is the effector of tumor suppressor activity of SEMA3B. PMID: 18985860
  24. SEMA3B plays role in inhibiting of growth of renal, ovarian and colorectal cancer cells. PMID: 19548530
  25. These data indicate that polymorphisms in SEMA3B are associated with prostate cancer risk and poor prognosis in Hispanic and nonHispanic white men PMID: 19683737
  26. Identification of semaphorin 3B as a direct target of p53. PMID: 11922394

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Subcellular Location
Secreted. Endoplasmic reticulum. Note=Accumulates in the endoplasmic reticulum.
Protein Families
Semaphorin family
Tissue Specificity
Expressed abundantly but differentially in a variety of neural and nonneural tissues.
Database Links

HGNC: 10724

OMIM: 601281

KEGG: hsa:7869

UniGene: Hs.82222

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