SH3BP4 Antibody

Code CSB-PA021225GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
SH3BP4
Alternative Names
BOG25 antibody; EH binding protein antibody; EH binding protein 10 antibody; EH-binding protein 10 antibody; EHB10 antibody; SH3 domain binding protein 4 antibody; SH3 domain-binding protein 4 antibody; SH3B4_HUMAN antibody; sh3bp4 antibody; Transferrin receptor trafficking protein antibody; Transferrin receptor-trafficking protein antibody; TTP antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human SH3BP4
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.
Gene References into Functions
  1. SH3BP4 has been identified as a novel pigmentation gene. The SH3BP4 is a direct target of miR-125b. The SH3BP4 is transcriptionally regulated by MITF as its direct target. PMID: 28819321
  2. SH3BP4 is a negative regulator of the Rag GTPase complex and amino acid-dependent mTORC1 signaling. PMID: 22575674
  3. Results show that TTP (SH3BP4), a SH3-containing protein, specifically regulates the internalization of the transferrin receptor (TfR). PMID: 16325581
Subcellular Location
Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.
Tissue Specificity
Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level).
Database Links

HGNC: 10826

OMIM: 605611

KEGG: hsa:23677

STRING: 9606.ENSP00000340237

UniGene: Hs.516777

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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