SLC13A2 Antibody

1. Homozygous GG of rs11567842 SNP in NaDC-1 gene was a protective genotype for hypocitraturia in kidney stone patients PMID: 30155711
2. Mapping Functionally Important Residues in the Na(+)/Dicarboxylate Cotransporter, NaDC1. PMID: 28731330
3. NaDC1 is present throughout the entire proximal tubule, but was not detected in kidney tumors. PMID: 27927654
4. cyclophilin isoform B is likely responsible for down-regulation of carrier expression by CsA and that it does so via its chaperone activity on NaDC1 (by direct interaction) rather than its rotamase activity. PMID: 21257749
5. study concludes most of the naturally occurring nonsynonymous SNPs affect protein processing of NaDC1; several also affect functional properties; mutations are predicted to decrease transport activity PMID: 20610529
6. This paper describes the cloning and functional characterization of the human Na(+)-coupled citrate transporter (NaCT). PMID: 12445824
7. Data show that the sodium-dependent dicarboxylate co-transporter protein 1 is located in renal proximal tubule lumenal membranes, and that the C-terminal sequence is required for delivery and targeting and may contain the signal sequence. PMID: 15620109
8. there are conformationally sensitive residues in extracellular loop 5 of the Na+/dicarboxylate co-transporter PMID: 15774465
9. B allele of I550V polymorphism of hNaDC-1 may be associated with a reduction in urinary citrate excretion and contribute to hypocitraturia in recurrent renal stone formers. PMID: 17470169
10. The Ser or Thr at position 509 is the most important determinant of functional differences in apparent affinity for substrate and cations. The cation and substrate binding sites are located in close proximity to one another. PMID: 18161988

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HGNC: 10917

OMIM: 604148

KEGG: hsa:9058

UniGene: Hs.102307