SLC30A6 Antibody

Code CSB-PA744010LA01HU
Size US$166
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  • Western blot
    All lanes: SLC30A6 antibody at 6µg/ml
    Lane 1: A549 whole cell lysate
    Lane 2: U251 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 52, 56, 48, 49 kDa
    Observed band size: 52 kDa

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA744010LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA744010LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA744010LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC30A6 Polyclonal antibody
Uniprot No.
Target Names
SLC30A6
Alternative Names
SLC30A6; ZNT6; Zinc transporter 6; ZnT-6; Solute carrier family 30 member 6
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Zinc transporter 6 protein (246-461AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SLC30A6 Antibody (Product code: CSB-PA744010LA01HU) is Non-conjugated. For SLC30A6 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA744010LB01HU SLC30A6 Antibody, HRP conjugated ELISA
FITC CSB-PA744010LC01HU SLC30A6 Antibody, FITC conjugated
Biotin CSB-PA744010LD01HU SLC30A6 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.
Gene References into Functions
  1. There was a significant increase in protein levels of ZnT6 in the prefrontal cortex in Major depression disorder, relative to control subjects. PMID: 27661418
  2. A genetic variant within SLC30A6 has a protective role in the severity of Rheumatoid Arthritis. PMID: 27758124
  3. results of this study suggested that ZnT6 protein levels are decreased in the spinal cords of sporadic ALS patients. PMID: 25284286
  4. The results of this study showed that signi fi cant positive correlations between ZIP1,ZnT1, and ZnT6 in most brain in patient with Alzheimer's disease. PMID: 22349685
  5. our results suggest that alterations in Zn transport proteins ZnT-1, ZnT-4 and ZnT-6 may contribute to the pathology observed in preclinical Alzheimer's disease subjects before onset of clinical symptoms PMID: 19371353
  6. Our results show that Zn transporter-4 and Zn transporter-6 are significantly (P<0.05) increased in hippocampus/parahippocampal gyrus of early Alzheimer's disease and Alzheimer's disease subjects. PMID: 16580781
  7. hZnT-6 is up-regulated in response to cellular zinc depletion in Raji & THP-1 cells. PMID: 17971500
  8. Data show that ZNT6 is extensively present in the Abeta-positive plaques in the cortex of human AD brains. PMID: 18639746
  9. The cytosolic C-terminal tail of ZnT5 is important for its interaction with ZnT6 as a heterodimer. PMID: 19759014

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Subcellular Location
Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
Protein Families
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily
Tissue Specificity
Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve,
Database Links

HGNC: 19305

OMIM: 611148

KEGG: hsa:55676

UniGene: Hs.23248

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