SLC38A9 Antibody

Code CSB-PA836713LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Jurkat whole cell lysate
    All lanes: SLC38A9 antibody at 3.5μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 64, 53, 57 kDa
    Observed band size: 64 kDa

  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA836713LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA836713LA01HU at dilution of 1:100

  • Immunofluorescent analysis of U251 cells using CSB-PA836713LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SLC38A9 Polyclonal antibody
Uniprot No.
Target Names
SLC38A9
Alternative Names
FLJ46104 antibody; FLJ90709 antibody; Homo sapiens solute carrier family 38; member 9 antibody; MGC120544 antibody; OTTHUMP00000161835 antibody; Putative sodium coupled neutral amino acid transporter 9 antibody; Putative sodium-coupled neutral amino acid transporter 9 antibody; Putative uncharacterized protein FLJ90709 antibody; S38A9_HUMAN antibody; SLC38A9 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Sodium-coupled neutral amino acid transporter 9 protein (1-119AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SLC38A9 Antibody (Product code: CSB-PA836713LA01HU) is Non-conjugated. For SLC38A9 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA836713LB01HU SLC38A9 Antibody, HRP conjugated ELISA
FITC CSB-PA836713LC01HU SLC38A9 Antibody, FITC conjugated
Biotin CSB-PA836713LD01HU SLC38A9 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids. Acts as an arginine sensor. Following activation by arginine binding, mediates transport of leucine, tyrosine and phenylalanine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation.
Gene References into Functions
  1. Ragulator and SLC38A9 act on the Rag GTPases to activate the mTORC1 pathway in response to nutrient sufficiency. PMID: 30181260
  2. Study validates that SLC38A9 is an arginine sensor for the mTORC1 pathway, and we uncover an unexpectedly central role for SLC38A9 in amino acid homeostasis. SLC38A9 mediates the transport, in an arginine-regulated fashion, of many essential amino acids out of lysosomes, including leucine, which mTORC1 senses through the cytosolic Sestrin proteins. PMID: 29053970
  3. Data suggest that amino acid transporter SLC38A9 controls mTORC1 activity through binding to the Rag-Ragulator complex at the lysosome upon amino acid availability. PMID: 25963655
  4. SLC38A9 is a physical and functional component of the amino acid sensing machinery that controls the activation of mTOR PMID: 25561175
  5. SLC38A9 functions upstream of the Rag GTPases and is an excellent candidate for being an arginine sensor for the mTORC1 pathway. PMID: 25567906
  6. SNPs within SLC38A9 are correlated with inflammatory bowel disease patients' 6-thioguanine nucleotide blood concentrations. PMID: 24762746

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Subcellular Location
Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein.
Protein Families
Amino acid/polyamine transporter 2 family, SLC38A9 subfamily
Database Links

HGNC: 26907

OMIM: 616203

KEGG: hsa:153129

STRING: 9606.ENSP00000316596

UniGene: Hs.742101

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