SLIT3 Antibody

Datasheet

Code	CSB-PA050101
Size	US$119
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

O75094

Target Names

SLIT3

Alternative Names

FLJ10764 antibody; KIAA0814 antibody; MEGF 5 antibody; MEGF5 antibody; Multiple EGF-like domains protein 5 antibody; Multiple epidermal growth factor like domains 5 antibody; Multiple epidermal growth factor-like domains protein 5 antibody; SLIL 2 antibody; SLIL2 antibody; SLIT 1 antibody; Slit 2 antibody; Slit 3 antibody; Slit homolog 3 (Drosophila) antibody; Slit homolog 3 antibody; Slit homolog 3 protein antibody; Slit-3 antibody; SLIT1 antibody; Slit2 antibody; Slit3 antibody; SLIT3_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human Slit3.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid

Tested Applications

IHC, ELISA

Recommended Dilution

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:40000

Protocols

Immunohistochemistry (IHC) Protocol
ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.

Gene References into Functions

Overexpression of Slit3 induces its tumor suppressive effects in Breast cancer. PMID: 26542734
Results show that silencing of Slit3 promoted proliferation, migration and invasion of A549 cells and induced epithelial-mesenchymal transition suggesting that Slit3 functions as a tumor suppressor in lung carcinoma. PMID: 26045181
Estrogen-dependent expression of SLIT3 may play a key role in regulating nerve-vessel interactions within the complex microenvironment of endometriosis lesions. PMID: 25051436
SLIT3 is increased with labour, and both amnion and myometrial studies describe a pro-inflammatory effect of SLIT3 in these tissues. PMID: 24286238
High SLIT3 expression is associated with high-grade gliomas. PMID: 24158112
SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo. PMID: 24090675
results implicate the involvement of miR-218-2 and its host gene SLIT3 in thyroid cancer cell invasion, migration, and proliferation PMID: 23720784
Slit3 treatment increased the in vivo homing efficiency of CD34 HSPCs to the BM in NOD/SCID mice, whereas Slit3-exposed HSPC migration in vitro was inhibited. Results support a role for Slit3 in human HSPC migration in vitro and homing in vivo. PMID: 22614124
SLIT3 duplication on 5q35.1 predisposes to major depressive disorder PMID: 21152026
The chemorepellent Slit3 promotes monocyte migration. PMID: 21078908
Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis. PMID: 20298552
Many variants in SLIT3 tend to associate with schizophrenia susceptibility in the Chinese Han population. PMID: 15231749
data suggest that Slit proteins play a key role in guiding dorsally projecting cranial motoneurons and in facilitating their neural tube exit PMID: 16162649
In fetal and embryonic stem cell cultures Slit-3 inhibited neurite outgrowth. PMID: 16840550
functions to promote angiogenesis in coordinating organogenesis during embryonic development PMID: 19741192

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Subcellular Location

Secreted.

Tissue Specificity

Predominantly expressed in thyroid.

Database Links

HGNC: 11087

OMIM: 603745

KEGG: hsa:6586

STRING: 9606.ENSP00000430333

UniGene: Hs.552087

Promotions

Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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