Product Details

Uniprot No.

Target Names

SMARCC1

Alternative Names

AI115498 antibody; BAF 155 antibody; BAF155 antibody; BRG 1 associated factor 155 antibody; BRG1 associated factor 155 antibody; BRG1-associated factor 155 antibody; Chromatin remodeling complex BAF155 subunit antibody; CRACC 1 antibody; CRACC1 antibody; Mammalian chromatin remodeling complex BRG 1 associated factor 155 antibody; Mammalian chromatin remodeling complex BRG1 associated factor 155 antibody; Rsc 8 antibody; Rsc8 antibody; SMARC C1 antibody; SMARCC 1 antibody; SMARCC1 antibody; SMRC1_HUMAN antibody; SRG 3 antibody; SRG3 antibody; SWI 3 antibody; SWI/SNF complex 155 kDa subunit antibody; SWI/SNF complex subunit SMARCC1 antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin c1 antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 1 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 antibody; SWI3 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human SMARCC1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

Gene References into Functions

Study found SMARCC1 as a direct target of miR-202-5p and promoted the growth and metastasis of colorectal carcinoma (CRC) cells. Furthermore, SMARCC1 could reverse the inhibitory effect of miR-202-5p on growth and metastasis of CRC cells. PMID: 30144500
our data showed that Swi3 strongly affects haem/oxygen-dependent activation of respiration gene promoters whereas Swi2 affects only the basal, haem-independent activities of these promoters. using computational analysis and RNAi knockdown, we showed that the mammalian Swi3 BAF155 and BAF170 regulate respiration in HeLa cells. PMID: 27190130
Results show the secondary structure of SWIRM domain of BAF155 consists of five alpha-helices forming a typical histone fold for DNA interactions. PMID: 23996527
we identify BAF155 as a substrate for arginine methyltransferase CARM1. PMID: 24434208
Wwp2 acts as a ubiquitin ligase of SRG3. PMID: 24365151
miR-320c regulates the resistance of pancreatic cancer cells to gemcitabine through SMARCC1. PMID: 23799850
loss of BAF155 expression represents another mechanism for inactivation of SWI/SNF complex activity in the development in human cancer. PMID: 22139574
Data show that the mechanism of BAF155-mediated stabilization of BAF57 involves blocking its ubiquitination by preventing interaction with TRIP12. PMID: 20829358
protein levels of BAF155/170 dictate the maximum cellular amount of BAF57 PMID: 16199878
Constitutive expression of SRG3 inhibits positive selection processes in T-cell receptor transgenic mice. PMID: 17513758
An increased expression of SMARCC1 protein was found in prostate cancer positively correlated with tumour dedifferentiation, progression, metastasis and time to recurrence. PMID: 18581278
patients with tumours displaying high levels of CBFB and SMARCC1 proteins had a significantly better overall survival rate than patients with low levels PMID: 19156145

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Subcellular Location

Nucleus. Cytoplasm.

Protein Families

SMARCC family

Tissue Specificity

Expressed in brain, heart, muscle, placenta, lung, liver, muscle, kidney and pancreas.

Database Links

HGNC: 11104

OMIM: 601732

KEGG: hsa:6599

STRING: 9606.ENSP00000254480

UniGene: Hs.476179

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Code	CSB-PA021806GA01HU
Size	$600
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SMARCC1 Antibody

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