SPACA3 Antibody

Code CSB-PA022454GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
SPACA3
Alternative Names
SPACA3 antibody; LYC3 antibody; LYZL3 antibody; SLLP1 antibody; SPRASA antibody; UNQ424/PRO862Sperm acrosome membrane-associated protein 3 antibody; Cancer/testis antigen 54 antibody; CT54 antibody; Lysozyme-like acrosomal sperm-specific secretory protein ALLP-17 antibody; Lysozyme-like protein 3 antibody; Sperm lysozyme-like protein 1 antibody; Sperm protein reactive with antisperm antibodies antibody; Sperm protein reactive with ASA) [Cleaved into: Sperm acrosome membrane-associated protein 3 antibody; membrane form; Sperm acrosome membrane-associated protein 3 antibody; processed form] antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human SPACA3
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.
Gene References into Functions
  1. The levels of antibodies reactive with SPRASA were elevated in infertile women. PMID: 25038051
  2. SLLP1 represents a promising target for the immunotherapy of multiple myeloma. PMID: 26088750
  3. Authors present evidence that the variants could affect the expression levels or function of SPRASA, thereby affecting a couple's fertility. PMID: 24872021
  4. SLLP1 could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane PMID: 12606493
  5. SLLP1 is capable of eliciting B-cell immune responses in vivo in cancer-bearing individuals. PMID: 15475442

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Subcellular Location
[Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type II membrane protein.; [Isoform 2]: Secreted.
Protein Families
Glycosyl hydrolase 22 family
Tissue Specificity
The processed form is expressed in sperm (at protein level). Expressed in testis, epididymis and placenta.
Database Links

HGNC: 16260

OMIM: 612749

KEGG: hsa:124912

STRING: 9606.ENSP00000269053

UniGene: Hs.434112

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