SPC24 Antibody

Datasheet

Code	CSB-PA836712LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA836712LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SPC24 Polyclonal antibody

Uniprot No.

Q8NBT2

Target Names

SPC24

Alternative Names

FLJ90806 antibody; hSpc24 antibody; Kinetochore protein Spc24 antibody; SPBC24 antibody; spc24 antibody; SPC24 NDC80 kinetochore complex component antibody; SPC24 NDC80 kinetochore complex component homolog antibody; SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) antibody; SPC24_HUMAN antibody; Spindle pole body component 24 homolog (S. cerevisiae) antibody; Spindle pole body component 24 homolog antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Kinetochore protein Spc24 protein (21-97AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SPC24 Antibody (Product code: CSB-PA836712LA01HU) is Non-conjugated. For SPC24 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA836712LB01HU	SPC24 Antibody, HRP conjugated	ELISA
FITC	CSB-PA836712LC01HU	SPC24 Antibody, FITC conjugated
Biotin	CSB-PA836712LD01HU	SPC24 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.

Gene References into Functions

SPC24 is up-regulated in human breast cancer.SPC24 regulates PI3K/AKT kinase pathway in breast cancer. PMID: 30180968
our data demonstrates that SPC24 can serve as a promising prognostic biomarker of anaplastic thyroid cancer cells PMID: 28423533
Data indicate that kinetochore protein Spc24 (SPC24) may be a promising molecular target for hepatocellular carcinoma (HCC) therapy. PMID: 26515591
hSPC24 is a component of the human NDC80 kinetochore complex PMID: 14699129

Subcellular Location

Nucleus. Chromosome, centromere, kinetochore.

Protein Families

SPC24 family

Database Links

HGNC: 26913

OMIM: 609394

KEGG: hsa:147841

STRING: 9606.ENSP00000465075

UniGene: Hs.381225

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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