SPRR1B Antibody

Datasheet

Code	CSB-PA022611LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA022611LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SPRR1B Polyclonal antibody

Uniprot No.

P22528

Target Names

SPRR1B

Alternative Names

14.9 kDa pancornulin antibody; Cornifin antibody; Cornifin B antibody; Cornifin-B antibody; CornifinB antibody; GADD33 antibody; MGC61901 antibody; Small proline rich protein IB antibody; Small proline-rich protein IB antibody; SPR-IB antibody; SPR1B_HUMAN antibody; SPRIB antibody; SPRR1 antibody; SPRR1B antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cornifin-B protein (1-89AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SPRR1B Antibody (Product code: CSB-PA022611LA01HU) is Non-conjugated. For SPRR1B Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA022611LB01HU	SPRR1B Antibody, HRP conjugated	ELISA
FITC	CSB-PA022611LC01HU	SPRR1B Antibody, FITC conjugated
Biotin	CSB-PA022611LD01HU	SPRR1B Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage.

Gene References into Functions

Expression of SPRR1 and of SPRR2A is increased in mucosal samples from patients with chronic rhinosinusitis and appeared as a downstream result of TNF alpha modulation, which possibly resulted in epithelial barrier dysfunction. PMID: 28859701
Levels SPRR1B proteins were significantly higher in AD skin compared with the levels of these proteins in the skin of healthy subjects. PMID: 27304082
expression of SPRR1B is upregulated in oral CSCs/CICs and SPRR1B has a role in cell growth by suppression of RASSF4 PMID: 23954638
BMK1 (ERK5) regulates squamous differentiation marker SPRR1B transcription in Clara-like H441 cells. PMID: 12091247
SPRR1B expression pattern in nonsquamous tumors; findings indicate SPRR1B likely coupled to signals responsible for withdrawal from the proliferative state; overexpression for prolonged periods may disrupt normal progression of mitosis PMID: 12832281
SPRR1B is a valid biomarker for the study of the molecular mechanisms of squamous metaplasia. There is a definitive link between inflammation and squamous metaplasia in autoimmune-mediated dry eye disease PMID: 18172072

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Subcellular Location

Cytoplasm.

Protein Families

Cornifin (SPRR) family

Tissue Specificity

Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea.

Database Links

HGNC: 11260

OMIM: 182266

KEGG: hsa:6699

STRING: 9606.ENSP00000306461

UniGene: Hs.1076

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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