STOML2 Antibody

1. TROP-2, SLP-2 and CD56 were effective diagnostic markers for PTC, especially when they were combined to use. PMID: 29951933
2. Data show that SLP-2 is upregulated by high cisplatin concentrations, leading to increased protein turnover. Overexpression of SLP-2 activates the MEK/ERK signaling pathway, and suppresses the mitochondrial apoptosis pathway, indicating that SLP-2 inhibits apoptosis by activating the MEK/ERK pathway and inhibiting the mitochondrial apoptosis pathway in cervical cancer cells. PMID: 29516570
3. The expression of STOML2, a gene that plays a key role in mitochondrial function and T-cell activation, is associated with both IL-6 signaling and asthma risk. PMID: 26932604
4. results reveal an important role of SLP2 membrane scaffolds for the spatial organization of inner membrane proteases regulating mitochondrial dynamics, quality control, and cell survival. PMID: 27737933
5. Slp2 is involved in endometrial stromal cell proliferation and differentiation during decidualization in mice and humans PMID: 27986413
6. The significant association of SLP-2 overexpression with unfavorable clinicopathological characteristics and BRAFV600E mutation indicates that SLP-2 may have a role in aggressiveness of BRAF-mutated papillary thyroid carcinoma. PMID: 26750533
7. Stomatin-like protein 2 is overexpressed in epithelial ovarian cancer and predicts poor patient survival PMID: 26487491
8. STOML2 was correlated to progression in cervical cancer, and implicated it as a potential predictive factor for the prognosis of cervical cancer. PMID: 25973071
9. Our study showed that STOML-2 was negatively regulated by miR1207-5p in esophageal carcinoma PMID: 25695396
10. SLP-2 was upregulated by TGF-beta1, indicating a possible role of SLP-2 in Papillary thyroid cancer tumorigenesis. PMID: 24190591
11. STOML2 may have a role in progression of gastric adenocarcinoma PMID: 24258357
12. Increased levels of SLP-2 correlate with lymph node metastasis in gastric cancer. PMID: 23371255
13. SLP-2 may play an important role in human GBC tumorigenesis, and SLP-2 might serve as a novel prognostic marker in human GBC. PMID: 23918306
14. Expression of SLP-2 is associated with invasion of esophageal squamous cell carcinoma. PMID: 23667687
15. SLP-2 deficiency in T-lymphocytes is associated with abnormal cardiolipin compartmentalization in mitochondrial membranes, defects associated with altered mitochondrial respiration that is increasingly uncoupled from ATP production. PMID: 23028053
16. [review] Stomatin family member STOML2 is oligomeric; it localizes mostly to membrane domains and has been shown to modulate ion channel activity. PMID: 21501885
17. SLP-2 facilitates the compartmentalization not only of mitochondrial membranes but also of the plasma membrane into functional microdomains. PMID: 22623988
18. investigation of biomarkers for early diagnosis of endometriosis: Data suggest that SLP2, tropomyosin 3, and tropomodulin 3 are autoantigens present in blood of women with endometriosis; immunodominant epitopes were identified. PMID: 22158085
19. SLP-2 and HER2/neu can play a role in lymph node/distant metastases of breast cancers PMID: 22081131
20. We propose that the function of SLP-2 is to recruit prohibitins to cardiolipin to form cardiolipin-enriched microdomains in which electron transport complexes are optimally assembled. PMID: 21746876
21. plasma concentrations of stomatin (EPB72)-like 2 in early-stage colorectal cancer patients were elevated as compared with those of healthy individuals PMID: 21209152
22. The dominant inheritance of hyperphosphorylated paratarg-7 explains cases of familial IgM monoclonal gammopathy of undetermined significance and Waldenstrom macroglobulinemia PMID: 21220746
23. negatively modulates mitochondrial sodium-calcium exchange PMID: 19944461
24. SLP-2 overexpression is associated with tumour distant metastasis and poor prognosis in pulmonary squamous cell carcinoma. PMID: 19839737
25. overexpression of stomatin-like protein 2 is associated with neoplasms PMID: 16533792
26. SLP-2 is a high abundance protein in several tissues and cells and may play an important biological role; this study uses mass spectrometry to analyze its primary structure PMID: 16671055
27. SLP-2 was overexpressed in endometrial adenocarcinoma compared with their normal counterparts. PMID: 17342323
28. High-level SLP-2 expression was associated with decreased overall survival (P = .011) and was more often found in patients with tumors larger than 20 mm, lymph node metastasis, advanced clinical stage, distant metastasis PMID: 17709317
29. SLP-2 is an important player in T cell activation by ensuring sustained TCR signaling PMID: 18641330
30. Familial MGUS and multiple myeloma were associated with a dominant inheritance of hyperphosphorylated paratarg-7 PMID: 19767238
31. Endosymbiotic origin of paraslipin from an alphaprotoebacterial ancestor (SLP-2) PMID: 18267007

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HGNC: 14559

OMIM: 608292

KEGG: hsa:30968

STRING: 9606.ENSP00000348886

UniGene: Hs.3439