THEMIS2 Antibody

Datasheet

Code	CSB-PA003594GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q5TEJ8

Target Names

THEMIS2

Alternative Names

Basement membrane induced antibody; Chromosome 1 open reading frame 38 antibody; ICB 1 antibody; ICB1 antibody; Induced by contact to basement membrane 1 protein antibody; Protein ICB 1 antibody; Protein ICB-1 antibody; Protein THEMIS2 antibody; THEMIS2 antibody; THMS2_HUMAN antibody; Thymocyte expressed molecule involved in selection protein 2 antibody; Thymocyte-expressed molecule involved in selection protein 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Human ICB-1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production. Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways.

Gene References into Functions

SNP rs1467465 of the human gene icb-1 might affect susceptibility to ovarian cancer. PMID: 24826199
Loss of icb-1 expression accelerated proliferation of SK-OV-3, OVCAR-3 and OAW-42 cells and led to upregulation of ovarian cancer biomarkers like KLK10 and CLDN16. PMID: 23474491
Data of this study suggest that icb-1 might exert a tumor-suppressor function in breast cancer and that its loss might confer relative resistance of breast cancer cells to apoptotic drugs. PMID: 22565810
Themis2 and Themis1 exhibit the same potential to restore T cell development and T cell receptor-mediated signaling in Themis1-deficient mice. PMID: 22732588
These findings together with the observed co-expression of icb-1 with E-cadherin in breast cancer samples support an important role of the icb-1 gene in cancer cell differentiation. PMID: 21455565
Data show that a highly significant positive correlation of icb-1 transcript levels with c-erbB2 (HER2) expression (p <.0001). PMID: 20569072
Identification of ICB-1 as a new player in endocrine-related cancer. PMID: 19942713
Increased icb-1 mRNA levels could be observed both in monocytic and granulocytic differentiation in maturing HL-60 cells. PMID: 12191572
The novel interferon-gamma inducible gene icb-1 is identified and its effects on the response of ovarian cancer cells to interferon-gamma are described PMID: 16219472
Data suggest that SNP rs1467465 of human gene icb-1 might affect breast cancer susceptibility. PMID: 19308812

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Subcellular Location

Nucleus. Cytoplasm.

Protein Families

Themis family

Tissue Specificity

Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1.

Database Links

HGNC: 16839

OMIM: 617856

KEGG: hsa:9473

STRING: 9606.ENSP00000363031

UniGene: Hs.10649

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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