TMPRSS11D Antibody

1. High HAT expression is associated with Idiopathic pulmonary fibrosis. PMID: 29122847
2. we conclude that TMPRSS11D could play a role in non-small cell lung cancer development and progression PMID: 28086212
3. HAT expression may potentially be useful as a marker for clinical grading and assessment of patient prognosis in squamous cell carcinomas PMID: 26297835
4. H9N2 viruses with R-S-S-R or R-S-R-R cleavage sites in hemagglutinin are activated by matriptase in addition to HAT and TMPRSS2 and, therefore, can be activated in a wide range of tissues what may affect virus spread, tissue tropism and pathogenicity. PMID: 23192872
5. TMPRSS2 and HAT are expressed by important influenza and SARS-coronavirus target cells and could thus support viral spread in the human host. PMID: 22558251
6. results suggest that HAI-1 functions as a physiological regulator of HAT by inhibiting its protease activity and proteolytic activation in airway epithelium.(HAT) PMID: 22023801
7. HAT cleaves proMSP at the physiological activation site PMID: 22245154
8. Human HAT cleaved severe acute respiratory syndrome coronavirus spike protein at R667, as determined by mutagenesis and mass spectrometry. PMID: 21994442
9. HAT regulates cellular functions of human bronchial epithelial cells via activation of protease-activated receptor-2. PMID: 12630574
10. HAT might promote PAR-2-mediated IL-8 production to accumulate inflammatory cells in the epidermal layer of psoriasis. PMID: 15102084
11. results indicate that HAT stimulates fibroblast proliferation in bronchial airways through a PAR-2-dependent MEK-MAPK mediated pathway and that HAT is linked to airway processes involving fibroblasts PMID: 16199437
12. HAT induces amphiregulin production through the PAR-2 mediated ERK pathway, and then causes amphiregulin release by a TACE-dependent mechanism PMID: 16336275
13. TMPRSS2 and HAT are candidates for proteolytic activation of influenza viruses in vivo PMID: 16973594

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HGNC: 24059

OMIM: 605369

KEGG: hsa:9407

STRING: 9606.ENSP00000283916

UniGene: Hs.132195