TNRC6C Antibody

Datasheet

Code	CSB-PA862070LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Hela whole cell lysate All lanes: TNRC6C antibody at 3.4μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 176, 180 kDa Observed band size: 176 kDa Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA862070LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TNRC6C Polyclonal antibody

Uniprot No.

Q9HCJ0

Target Names

TNRC6C

Alternative Names

KIAA1582 antibody; TNR6C_HUMAN antibody; TNRC 6C antibody; Tnrc6c antibody; Trinucleotide repeat containing 6C antibody; Trinucleotide repeat containing gene 6C protein antibody; Trinucleotide repeat-containing gene 6C protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Trinucleotide repeat-containing gene 6C protein (157-421AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TNRC6C Antibody (Product code: CSB-PA862070LA01HU) is Non-conjugated. For TNRC6C Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA862070LB01HU	TNRC6C Antibody, HRP conjugated	ELISA
FITC	CSB-PA862070LC01HU	TNRC6C Antibody, FITC conjugated
Biotin	CSB-PA862070LD01HU	TNRC6C Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.

Gene References into Functions

These findings reveal that despite species-specific differences in the relative strength of the PABPC1-binding sites, the interaction between GW182 proteins and PABPC1 is critical for miRNA-mediated silencing in animal cells. PMID: 21063388
The authors show that a conserved motif in the human GW182 paralog TNRC6C interacts with the C-terminal domain of polyadenylate binding protein 1 (PABC) and present the crystal structure of the complex. PMID: 20098421
Through deletion and mutagenesis, study identified the C-terminal part of TNRC6C encompassing the RRM RNA-binding motif as a key effector domain mediating protein synthesis repression by TNRC6C. PMID: 19304925
Our findings indicate that TNRC6C, is recruited to miRNA targets through an interaction between their N-terminal domain and an Argonaute protein PMID: 19383768

Protein Families

GW182 family

Database Links

HGNC: 29318

OMIM: 610741

KEGG: hsa:57690

STRING: 9606.ENSP00000336783

UniGene: Hs.406810

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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