TUBA4A Antibody

1. Data indicate a microRNA-1825/TBCB/TUBA4A pathway as a putative pathogenic cascade in both familial ALS (fALS) and both sporadic (sALS). PMID: 30030593
2. The elevated selenium species levels in the TUBA4A patient may have a genetic etiology and/or represent a pathogenic pathway through which this mutation favors disease onset. PMID: 28478440
3. alphaTubulin expression might be an independent prognostic factor for pancreatic cancer after surgical resection PMID: 27447976
4. Its mutations were seen in patients with ALS and frontotemporal dementia. PMID: 28069311
5. TUBA4A mutations are not associated with FTD. PMID: 26675813
6. In conclusion, our current results did not find an association between TUBA4A and ALS in Chinese patients, and further studies will be required. PMID: 26465396
7. This study mutational screening revealed the presence of four novel heterozygous variants of TUBA4A mutation in four sporadic amyotrophic lateral sclerosis. PMID: 25893256
8. Data show that overexpression of the 14-3-3sigma isoform resulted in a disruption of the tubulin cytoskeleton mediated by binding Tau protein. PMID: 26103986
9. TUBA4A mutants destabilize the microtubule network, diminishing its repolymerization capability PMID: 25374358
10. TUBA4A is significantly increased in spermatazoa from men with azoospermia. PMID: 24268707
11. The results suggested that cytoskeletal alterations in the amygdala determined by tubulin seem to be involved in the pathophysiology of drug addiction PMID: 20686780
12. Subunits of alphaB crystallin that exchange dynamically with the alphaB crystallin complex can interact with tubulin subunits to regulate the equilibrium between tubulin and microtubules. PMID: 20668689
13. increased levels in paclitaxel-resistant breast cancer cells PMID: 12054644
14. Some protein-protein interactions in rafts were disrupted in 3-nitrotyrosine-containing proteins, e.g. caveolin-1 was dissociated from a complex with flotillin-1 and alpha-tubulin. PMID: 15934946
15. Our results suggest that MIZIP might play an important role in mammalian cells by associating with tubulin and thus might provide a link between MCHR1 and tubulin functions. PMID: 16039987
16. These results provide the first characterisation of endogenously nitrated tubulin from human tumour samples. PMID: 16257120

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HGNC: 12407

OMIM: 191110

KEGG: hsa:7277

STRING: 9606.ENSP00000248437

UniGene: Hs.75318