UBASH3A Antibody

1. UBASH3A gene SNP is associated with susceptibility to atopic dermatitis in Chinese Han population. PMID: 28747736
2. UBASH3A attenuates the NF-kappaB signal transduction upon T-cell receptor (TCR) stimulation by specifically suppressing the activation of the IkappaB kinase complex. UBASH3A interacts with TAK1 and NEMO, suggesting that UBASH3A regulates the NF-kappaB signaling pathway by an ubiquitin-dependent mechanism. T1D risk alleles at rs11203203 and rs80054410 increase UBASH3A expression in CD4(+) T cells upon TCR stimulation. PMID: 28607106
3. A negative correlation was found between UBASH3A mRNA expression and systemic lupus erythematosus. PMID: 25876712
4. Findings suggest that UBASH3A gene might contribute to systemic lupus erythematosus susceptibility and influence the clinical phenotype of the disease. PMID: 25843625
5. these results have suggested that the allele A of two SNPs may play no role in the pathogenesis of autoimmune thyroid disease or that its effect may be confounded by other various factors. PMID: 25211447
6. Addition of PTPN22 and UBASH3A SNPs to HLA-DR,DQ genotyping can improve type 1 diabetes risk prediction. PMID: 25075402
7. Results suggest that UBASH3a gene plays a role in the susceptibility to systemic lupus erythematosus and UBASH3a can be considered as a common genetic factor in autoimmune diseases. PMID: 23565265
8. ubiquitin associated and SH3 domain containing A appears to be an independent predictor of islet autoimmunity and type 1 diabetes in children, including those free of family history of T1D but carrying the HLA-DR3/4,DQB1*0302 genotype PMID: 22776074
9. The UBASH3A promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells. PMID: 20494980
10. Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases PMID: 15159412
11. TULA inhibits both clathrin-dependent and clathrin-independent endocytic pathways by functionally sequestering dynamin via the SH3 domain of TULA binding proline-rich sequences in dynamin PMID: 17382318
12. TULA enhances the apoptotic effect of AIF by facilitating the interactions of AIF with its apoptotic co-factors PMID: 17709377
13. Binds to ABCE-1 and inhibits HIV-1 life cycle, most likely by disrupting essential ubiquitylation-dependent events. PMID: 18006034
14. TULA proteins TULA and TULA-2 regulate activity of the protein tyrosine kinase Syk PMID: 18189269

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HGNC: 12462

OMIM: 605736

KEGG: hsa:53347

STRING: 9606.ENSP00000317327

UniGene: Hs.473912