UBE2W Antibody

Code CSB-PA842638LA01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) UBE2W Polyclonal antibody
Uniprot No.
Target Names
UBE2W
Alternative Names
FLJ11011 antibody; hUBC 16 antibody; hUBC16 antibody; Probable ubiquitin conjugating enzyme E2 W antibody; Probable ubiquitin-conjugating enzyme E2 W antibody; UBC 16 antibody; UBC-16 antibody; UBC16 antibody; UBE 2W antibody; ube2w antibody; UBE2W_HUMAN antibody; Ubiquitin carrier protein W antibody; Ubiquitin conjugating enzyme 16 antibody; Ubiquitin conjugating enzyme E2 W antibody; Ubiquitin conjugating enzyme E2W antibody; Ubiquitin protein ligase W antibody; Ubiquitin-protein ligase W antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ubiquitin-conjugating enzyme E2 W protein (1-151AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The UBE2W Antibody (Product code: CSB-PA842638LA01HU) is Non-conjugated. For UBE2W Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA842638LB01HU UBE2W Antibody, HRP conjugated ELISA
FITC CSB-PA842638LC01HU UBE2W Antibody, FITC conjugated
Biotin CSB-PA842638LD01HU UBE2W Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. UBE2W-catalyzed ubiquitination occurs also in the presence of inactive RING/U-box type E3s, i.e. lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate.
Gene References into Functions
  1. Thus, although Rnf4 and Ube2w functionally interact in vitro, these genetic experiments indicate that in response to DNA damage Ube2w and Rnf4 function in distinct pathways. PMID: 27185577
  2. TRIM5alpha requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription. PMID: 26101372
  3. We show the ubequitin-conjugating enzyme (E2) Ube2w uses a unique mechanism to facilitate the specific ubiquitination of the alpha-amino group PMID: 25436519
  4. Ube2w has novel enzymatic properties that direct ubiquitination of the N terminus of substrates PMID: 23696636
  5. UBE2W regulates FANCD2 monoubiquitination by mechanisms different from UBE2T and HRR6. PMID: 21229326
  6. human Ubiquitin-conjugating enzyme (E2) is homologous to the Arabidopsis thaliana UBC-16 gene product and contains 2 nuclear localization signals PMID: 16368532

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Subcellular Location
Nucleus.
Protein Families
Ubiquitin-conjugating enzyme family
Tissue Specificity
Widely expressed, with highest expression in brain, liver, pancreas and heart.
Database Links

HGNC: 25616

OMIM: 614277

KEGG: hsa:55284

STRING: 9606.ENSP00000454445

UniGene: Hs.128841

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