VENTX Antibody

1. Findings suggest potential applications of homeobox protein VentX (VentX)-regulated tumor-associated macrophages (TAMs) in cancer immunotherapy. PMID: 29872044
2. VENTX impairs expression of genes involved in erythroid differentiation and is highly expressed in patients with acute erythroid leukemia. PMID: 27888632
3. VentX induces apoptosis of cancer cells in a p53-independent manner PMID: 27175592
4. Data suggest that homeobox transcription factor VentX may be a target to modulate Dendritic cells (DCs) functions and manage inflammatory diseases. PMID: 24706756
5. VentX regulates critical cell cycle regulators and Wnt downstream genes previously implicated in HSC/MPP proliferation and expansion. PMID: 22791709
6. Results provide mechanistic insight into the crucial roles of VentX in macrophage differentiation and proinflammatory activation and suggest that dysregulation of VentX may play a role in the pathogenesis of autoimmune diseases. PMID: 21670496
7. Data show that VentX is a direct transcriptional activator of p53-p21 and p16ink4a-Rb tumor suppression pathways. PMID: 21325273
8. these data extend our insights into the function of embryonic mesodermal factors in human postnatal hematopoiesis and indicate a role for VENTX in normal and malignant myelopoiesis. PMID: 20833819
9. a potential role of VentX in the clinical behavior of hematopoietic malignancies. PMID: 20028861

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HGNC: 13639

OMIM: 607158

KEGG: hsa:27287

STRING: 9606.ENSP00000357556

UniGene: Hs.125231