ACE2 Antibody

Code CSB-PA325032XA01SVG
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Product Details

Full Product Name Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ACE2 Polyclonal antibody
Uniprot No. P21192
Target Names ACE2
Alternative Names ACE2 antibody; YLR131C antibody; L3123 antibody; L9606.10Metallothionein expression activator antibody
Raised in Rabbit
Species Reactivity Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ACE2 protein
Immunogen Species Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

Function
(From Uniprot)
Plays a role in regulating basal-level expression of CUP1. Activates EGT2 transcription in the absence of SWI5.
Gene References into Functions
  1. ACE2, a transcription factor required for septum destruction after cytokinesis, is a negative regulator of ethanol tolerance. PMID: 29789541
  2. Therefore, Ace2 and Swi5 are two negative regulators of ethanol yield during static fermentation of yeast cells, and both CTS1 and RPS4a are major effectors mediating these two transcription factors in regulating ethanol production. PMID: 26975390
  3. Data show that mutation of the Rts1 regulatory subunit of PP2A phosphatase (PP2ARts1 phosphatase) results in decreased HO endonuclease expression due to altered localization of the Ace2 transcription factor. PMID: 25352596
  4. Genome duplication and mutations in ACE2 cause multicellular, fast-sedimenting phenotypes in evolved Saccharomyces cerevisiae. PMID: 24145419
  5. show that Ace2 asymmetry is initiated in the elongated, but undivided, anaphase nucleus PMID: 22711697
  6. Data show that Ace2's nuclear localization is maintained by continuous Cbk1 activity and that inhibition of the kinase leads to immediate loss of phosphorylation and export to the cytoplasm. PMID: 20573982
  7. Regulation of CLN3 expression by Ace2 and Ash1 can account for the differential regulation of Start in response to cell size in mothers and daughters. PMID: 19841732
  8. Phosphorylation of the C-terminal site of Cbk1 is regulated over the cell cycle and requires Ace2 as well as all RAM network components.Ace2 is not only a downstream target of Cbk1 but also reinforces activation of its upstream regulator. PMID: 17145962
  9. In the daughter cell nucleus Cbk1p phosphorylates the Ace2p nuclear export signal, and the phosphorylation blocks the export of Ace2p via Crm1p. PMID: 18076379
  10. the precise timing of Ace2 accumulation in the nucleus involves both a nuclear export sequence and a nuclear localization signal, whose activities are regulated by phosphorylation PMID: 18292088

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Subcellular Location Nucleus.
Database Links

KEGG: sce:YLR131C

STRING: 4932.YLR131C

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