ACE2

What is ACE2?

Angiotensin-converting enzyme 2 (ACE2), also known as ACAH, is a protein in humans that is encoded by ACE2 gene. It was identified as the first reported ACE homologue in 2000. The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidylcarboxydipeptidases. Both ACE2 and ACE belong to the renin-angiotensin-aldosterone system (RAAS) and kallikrein-bradykinin system (KKS) families. ACE2 is a metalloproteinase with a total length of 805 amino acids. It is a type I transmembrane glycoprotein with a single extracellular catalytic domain. The human ACE2 gene has been cloned and mapped to the X chromosome.

What is the feature of ACE2 structure?

Like ACE, ACE2 has two domains: an amino-terminal catalytic domain and a carboxy-terminal domain. The catalytic domain has an active site called the zinc metallopeptidase domain (HEXH motif) and shows 41.8% sequence identity with the amino domain of ACE. The carboxy-terminal domain of ACE2 has 48% sequence identity with Collectrin. Collectrin is a non-catalytic protein that has key roles in renal amino acid reabsorption, pancreatic β-cell proliferation, and possible insulin exocytosis.

What is the function of ACE2?

Earlier studies revealed that ACE2 is mainly localized in the heart, kidney, and testis, and is expressed at low levels in many other tissues, especially the colon and lung. Later studies have also shown that ACE2 also plays an important role in other organs such as the liver and intestine. ACE2 is an important regulatory molecule of the renin-angiotensin system (RAS), which plays an important role in normal physiological activities to control cardiovascular and blood pressure. In addition, ACE2 is a receptor for SARS and other related viruses, and plays a key role in virus invasion.

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Hot products of ACE2:

Recombinant Human ACE2, partial (Active) (CSB-MP866317HU)

ACE2 Antibody (ELISA, IHC, IF) (CSB-PA866317LA01HU)

Human ACE2 ELISA Kit (CSB-E04489h)

ACE2 Antibodies

ACE2 Antibodies for Homo sapiens (Human)

ACE2 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

ACE2 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

ACE2 Antibodies for Rattus norvegicus (Rat)

ACE2 Proteins

ACE2 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

ACE2 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

ACE2 Proteins for Felis catus (Cat) (Felis silvestris catus)

ACE2 Proteins for Paguma larvata (Masked palm civet)

ACE2 Proteins for Bos taurus (Bovine)

ACE2 Proteins for Rattus norvegicus (Rat)

ACE2 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

ACE2 Proteins for Hypocrea jecorina (Trichoderma reesei)

ACE2 Proteins for Mus musculus (Mouse)

ACE2 Proteins for Homo sapiens (Human)

ACE2 ELISA Kit

ACE2 ELISA Kit for Homo sapiens (Human)

ACE2 ELISA Kit for Mus musculus (Mouse)

ACE2 ELISA Kit for Rattus norvegicus (Rat)

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