Alas1 Antibody

1. RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice. PMID: 24821812
2. Both ALAS1 mRNA and protein content were induced in diabetic animals, accompanied by decreased Akt phosphorylation and increased nuclear FOXO1, PGC-1alpha and FOXO1-PGC-1alpha complex levels. PMID: 22070747
3. active site functional asymmetry extends to chimeric ALAS/AONS proteins, which while having a different oligomeric state, exhibit different rates of product release from the two ALAS and two AONS active sites due to the created intermolecular strain PMID: 21600186
4. Egr-1 regulates the transcriptional repression of mouse delta-aminolevulinic acid synthase 1 by heme PMID: 21044876
5. Mice bearing a homozygous knock-in allele were lethal by embryonic day 8.5, demonstrating that ALAS-N is essential for early embryogenesis. PMID: 20015225
6. Ser-254 is critical for formation of a competent catalytic complex by coupling succinyl-CoA binding to enzyme conformational equilibria PMID: 19917609
7. identified a drug-responsive enhancer in the ALAS1 gene PMID: 12881517
8. Histidine-282 impacts a variety of ALAS functions, including substrate and pyridoxal 5'-phosphate (PLP)-binding and catalysis. PMID: 17469798
9. 5-aminolevulinate synthase operates under the stereoelectronic control predicted by Dunathan's hypothesis PMID: 17485466
10. The findings show that a B2 SINE retrotransposon can contribute to the regulation of ALAS1 and SINEs in 5'-UTR regions contribute to inter-individual differences in gene expression. PMID: 18929534

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KEGG: mmu:11655

STRING: 10090.ENSMUSP00000108143

UniGene: Mm.290578