becn1 Antibody

Code CSB-PA198001XA01DIL
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Product Details

Full Product Name Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) becn1 Polyclonal antibody
Uniprot No. F1RCP1
Target Names becn1
Alternative Names becn1Beclin-1 antibody
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) becn1 protein
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

Function
(From Uniprot)
Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis including endosome formation in neuronal cells.
Gene References into Functions
  1. Beclin1 plays an important role in vincristine-induced dopaminergic neurons toxicity. PMID: 25212030
Subcellular Location Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Endosome. Cytoplasmic vesicle, autophagosome.
Protein Families Beclin family
Database Links

KEGG: dre:393846

STRING: 7955.ENSDARP00000100986

UniGene: Dr.82731

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