Your Good Partner in Biology Research
Your Good Partner in Biology Research
| Code | CSB-PA004966ZA01BO |
| Size |
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| Full Product Name | Rabbit anti-Bos taurus (Bovine) CD8A Polyclonal antibody |
| Uniprot No. | P31783 |
| Target Names | CD8A |
| Alternative Names | CD8AT-cell surface glycoprotein CD8 alpha chain antibody; CD antigen CD8a antibody |
| Raised in | Rabbit |
| Species Reactivity | Bos taurus |
| Immunogen | Recombinant Bovine T-cell surface glycoprotein CD8 alpha chain (CD8A), partial (26-189AA) |
| Immunogen Species | Bos taurus (Bovine) |
| Conjugate | Non-conjugated |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification Method | Protein A/G |
| Concentration | It differs from different batches. Please contact us to confirm it. |
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Form | Liquid |
| Tested Applications | ELISA, WB (ensure identification of antigen) |
| Protocols | ELISA Protocol |
| Troubleshooting and FAQs | Antibody FAQs |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Value-added Deliverables | ① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control); |
| Quality Guarantee | ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive; |
| Lead Time | Made-to-order (12-14 weeks) |
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| Function (From Uniprot) |
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
| Database Links |
KEGG: bta:281060 STRING: 9913.ENSBTAP00000028175 UniGene: Bt.50 |
