Cdk1 Antibody

1. Cdk1 waves are not controlled by the mitotic switch but by a double-negative feedback between Cdk1 and Chk1. In Drosophila embryos, Cdk1 positive feedback serves primarily to ensure the rapid onset of mitosis, while wave propagation is regulated by S phase events. PMID: 27554859
2. Cdk1 phosphorylates the conserved centriole protein Sas-4 during mitosis. This creates a Polo-docking site that helps recruit Polo to daughter centrioles. PMID: 27326932
3. Our results indicate that the cyclic changes in Gwl localization at mitotic entry and exit are directly regulated by the antagonistic cyclin B-Cdk1 and PP2A-Tws enzymes PMID: 26761639
4. Cdk1 mediates the role of TARA and CycA in sleep regulation. PMID: 26096977
5. Y15 phosphorylation can both inhibit Cdk1 catalytic activity and de-stabilize Cdk1/Cyclin complexes, whereas T161 phosphorylation facilitates stable interactions between cyclin B and Cdk1. PMID: 25483135
6. Phosphorylation of Cdk1 on Y15 appeared to be crucial for developmental and DNA damage-induced G2-phase checkpoint arrest, consistent with other evidence that Myt1 is the major Y15-directed Cdk1 inhibitory kinase at this stage of development. PMID: 24214341
7. nonmuscle myosin II regulation by Cdc2 activity PMID: 12105185
8. CDK1 activation may be the cell cycle regulated event that determines the timing of emi1 destruction. PMID: 12820955
9. Data show that down-regulation of Cdc2 delayed pI mitosis and altered the polarity and the number of subsequent cell divisions. PMID: 15581871
10. Our findings suggest a model where mitotic disassembly/reassembly of the NPCs is regulated by a dynamic equilibrium of Cdk1 and OA-sensitive phosphatase activities and provide evidence that mitotic phosphorylation mediates disassembly of the NPC. PMID: 16120647
11. These results show that the two potential Cdk1 phosphorylation sites on Drosophila Cdc27 are required for its chromosomal localisation during mitosis and imply that these localisations specific to Cdc27 are crucial for APC/C functions. PMID: 17519285
12. Based on the results obtained, it was presupposed that distribution of annulate lamellae containing cytoplasmic pores could reflect the inactivation of the mitotic kinase cdk1 in Drosophila syncytial embryos. PMID: 18822788

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KEGG: dme:Dmel_CG5363

STRING: 7227.FBpp0079641

UniGene: Dm.3187