CR3L2 Antibody

Code CSB-PA005950XA01DIL
Product Type Polyclonal Antibody
Uniprot No. A1L224
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) CR3L2 protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Cyclic AMP-responsive element-binding protein 3-like protein 2 (cAMP-responsive element-binding protein 3-like protein 2) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 2] creb3l2 zgc:158603
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names creb3l2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/mbtps1 and S2P/mbtps2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis. May protect neuroblastoma cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site.
Subcellular Location Endoplasmic reticulum membrane, Single-pass type II membrane protein, Note=ER membrane resident protein, Upon ER stress, translocated to the Golgi apparatus where it is cleaved, The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus, SUBCELLULAR LOCATION: Processed cyclic AMP-responsive element-binding protein 3-like protein 2: Nucleus
Protein Families BZIP family, ATF subfamily
Database Links

KEGG: dre:791169

STRING: 7955.ENSDARP00000087416

UniGene: Dr.80606

Pathway cAMP signaling pathway
Estrogen signaling pathway
PI3K-Akt signaling pathway
TNF signaling pathway
Th17 cell differentiation
Thyroid hormone synthesis
AMPK signaling
cGMP-PKG signaling pathway
Glucagon signaling pathway

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