Camk4 Antibody

1. study demonstrates that CaMKIV can relieve STZ-induced diabetic neuropathic pain.pCaMKIV can regulate the expression of High-mobility group box 1 based on both cellular and animal models. PMID: 27216039
2. We find that synaptic excitation and intrinsic excitability are coregulated in individual neurons through CaMKIV signaling, which is tightly controlled by neuronal activity. In contrast, synaptic inhibition is unaffected by changes in firing or CaMKIV signaling in individual neurons. PMID: 28592691
3. Camk4 expression in the cortical subplate was prolonged in developmentally hypothyroid pups, whereas heavy Camk4 expression in layer VIb remains at P60. Abnormal expression of Camk4 might cause altered cortical connectivity. PMID: 23680840
4. We have determined that high levels of CaMKIV protein are expressed by IB4-binding sensory neurons of the dorsal root ganglion PMID: 23817991
5. CaMKIV contributes to the diversity of dendrite arbors via restricted expression and regulation of distinct modes of dendrite elaboration. PMID: 21989476
6. These results suggest that NR2B-containing NMDARs have a positive role in regulating neural progenitor cell proliferation, which may be mediated through CaMKIV phosphorylation and subsequent induction of CREB activation. PMID: 21762679
7. Study provides correlative evidence for the neuroprotective cascade of CaMKIV/ peroxisome proliferator-activated receptor gamma coactivator-1alpha in delayed neuronal cell death and mitochondrial biogenesis in the hippocampus PMID: 20799369
8. abnormal regulation of CaMKIV is a component of beta-cell dysfunction caused by high glucose. PMID: 20423744
9. Activation of the CaMKK/CaMKIV cascade by exendin-4 stimulated ABCA1 gene transcription, indicating that exendin-4 plays an important role in insulin secretion and cholesterol ester content in pancreatic beta cells. PMID: 19874424
10. Camk4 is regulated directly by triiodothyronine in primary cultured neurons from fetal cortex, and the Camk4 protein is also induced by thyroid hormone. PMID: 20056827
11. Calcium-induced dendritic growth is regulated by activation of a transcriptional program that involves CaM kinase IV-mediated signaling to the nucleus. PMID: 12086646
12. demonstrated regulation of endogenous CaMKIV by T3 in embryonic stem (ES) cells differentiated into neurons and identified a single complex element in the CaMKIV 5'-flanking region that confers this regulation PMID: 12403833
13. Thr196 phosphorylation of CaM-KIV by CaM-KK reduces interaction of the catalytic core with the autoinhibitory region, resulting in generation of the autonomous activity PMID: 15262966
14. the CaM-KK-CaM-KIV cascade probably plays an important role in thyroid releasing hormone induction of thyroid stimulating hormone and prolactin transcriptional activity in pituitary cells. PMID: 15308608
15. study establishes nuclear m-calpain as a regulator of CaMKIV and associated signaling molecules under conditions of sustained Ca(2+) influx PMID: 15537635
16. Expression of active CaMKIV caused an enhancement of both NMDA receptor-mediated synaptic responses and long-term potentiation. This was accompanied by changes consistent with the generation of "silent synapses". PMID: 15748849
17. CaMKIV signaling stimulates vitamin D receptor (VDR)-mediated transcription by PMID: 15919723
18. These results suggest that a signaling mechanism that involves CaMKIV/PKD and PP2A controls YY1 function through regulation of HDAC5 and is important in the maintenance of muscle differentiation. PMID: 16822951
19. Lithium administration reduced CREB phosphorylation and at the same time down-regulated CaMKIV (enzymatic activity, phospho-Thr196 and protein expression level) in cell nuclei from the hippocampus. PMID: 16923323
20. Calcineurin A and CaMKIV triggers PGC-1alpha promoter transactivation to drive the expression of non-mitochondrial proteins. PMID: 17273866
21. CaMKIV activates OGT (o-linked GlcNAc transferase), and OGT has an essential role on the process of CaMKIV-dependent AP-1 activation under depolarization in neuronal cells. PMID: 18029144
22. Activation of calcium/calmodulin-dependent kinase IV is necessary for brain-derived neurotrophic factor (BDNF)-induced phosphorylation of CREB and subsequent block of myelin-mediated inhibition of axonal growth. PMID: 18381242
23. TRPC6, a member of the TRPC family, promotes hippocampal neuron dendritic growth. PMID: 18559891
24. analysis of regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification PMID: 19506079
25. CaMKIV is regulated by the Wnt signaling pathway. CaMKIV expression could play a role in the neuroprotective function of Wnt signaling against the Alzheimer's amyloid peptide. PMID: 19711354

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KEGG: rno:25050

STRING: 10116.ENSRNOP00000027771

UniGene: Rn.11046