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Code | CSB-PA004471ZA01RA |
Size | Enquire |
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Full Product Name | Rabbit anti-Rattus norvegicus (Rat) Camk4 Polyclonal antibody |
Uniprot No. | P13234 |
Target Names | Camk4 |
Alternative Names | Camk4 antibody; Calcium/calmodulin-dependent protein kinase type IV antibody; CaMK IV antibody; EC 2.7.11.17 antibody; CaM kinase-GR antibody; Calspermin antibody |
Raised in | Rabbit |
Species Reactivity | Rattus norvegicus |
Immunogen | Recombinant Rattus norvegicus Camk4 protein |
Immunogen Species | Rattus norvegicus (Rat) |
Conjugate | Non-conjugated |
Clonality | Polyclonal |
Isotype | IgG |
Purification Method | Protein A/G |
Concentration | It differs from different batches. Please contact us to confirm it. |
Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Form | Liquid |
Tested Applications | ELISA, WB (ensure identification of antigen) |
Protocols | ELISA Protocol |
Troubleshooting and FAQs | Antibody FAQs |
Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
Value-added Deliverables | ① 200ug * antigen (positive control); ② 1ml * Pre-immune serum (negative control); |
Quality Guarantee | ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection; ② ELISA titer can be guaranteed 1: 64,000; ③ WB validation with antigen can be guaranteed positive; |
Lead Time | Made-to-order (12-14 weeks) |
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Function (From Uniprot) |
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.; Heat-stable, acidic, calmodulin-binding protein. |
Gene References into Functions |
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Subcellular Location | Cytoplasm. Nucleus. |
Protein Families | Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily |
Tissue Specificity | Isoform 1 is expressed in brain and isoform 2 is testis specific. |
Database Links |
KEGG: rno:25050 STRING: 10116.ENSRNOP00000027771 UniGene: Rn.11046 |