Camk4 Antibody

Code CSB-PA004471ZA01RA
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Product Details

Full Product Name Rabbit anti-Rattus norvegicus (Rat) Camk4 Polyclonal antibody
Uniprot No. P13234
Target Names Camk4
Alternative Names Camk4 antibody; Calcium/calmodulin-dependent protein kinase type IV antibody; CaMK IV antibody; EC 2.7.11.17 antibody; CaM kinase-GR antibody; Calspermin antibody
Raised in Rabbit
Species Reactivity Rattus norvegicus
Immunogen Recombinant Rattus norvegicus Camk4 protein
Immunogen Species Rattus norvegicus (Rat)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (12-14 weeks)

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Target Background

Function
(From Uniprot)
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.; Heat-stable, acidic, calmodulin-binding protein.
Gene References into Functions
  1. study demonstrates that CaMKIV can relieve STZ-induced diabetic neuropathic pain.pCaMKIV can regulate the expression of High-mobility group box 1 based on both cellular and animal models. PMID: 27216039
  2. We find that synaptic excitation and intrinsic excitability are coregulated in individual neurons through CaMKIV signaling, which is tightly controlled by neuronal activity. In contrast, synaptic inhibition is unaffected by changes in firing or CaMKIV signaling in individual neurons. PMID: 28592691
  3. Camk4 expression in the cortical subplate was prolonged in developmentally hypothyroid pups, whereas heavy Camk4 expression in layer VIb remains at P60. Abnormal expression of Camk4 might cause altered cortical connectivity. PMID: 23680840
  4. We have determined that high levels of CaMKIV protein are expressed by IB4-binding sensory neurons of the dorsal root ganglion PMID: 23817991
  5. CaMKIV contributes to the diversity of dendrite arbors via restricted expression and regulation of distinct modes of dendrite elaboration. PMID: 21989476
  6. These results suggest that NR2B-containing NMDARs have a positive role in regulating neural progenitor cell proliferation, which may be mediated through CaMKIV phosphorylation and subsequent induction of CREB activation. PMID: 21762679
  7. Study provides correlative evidence for the neuroprotective cascade of CaMKIV/ peroxisome proliferator-activated receptor gamma coactivator-1alpha in delayed neuronal cell death and mitochondrial biogenesis in the hippocampus PMID: 20799369
  8. abnormal regulation of CaMKIV is a component of beta-cell dysfunction caused by high glucose. PMID: 20423744
  9. Activation of the CaMKK/CaMKIV cascade by exendin-4 stimulated ABCA1 gene transcription, indicating that exendin-4 plays an important role in insulin secretion and cholesterol ester content in pancreatic beta cells. PMID: 19874424
  10. Camk4 is regulated directly by triiodothyronine in primary cultured neurons from fetal cortex, and the Camk4 protein is also induced by thyroid hormone. PMID: 20056827
  11. Calcium-induced dendritic growth is regulated by activation of a transcriptional program that involves CaM kinase IV-mediated signaling to the nucleus. PMID: 12086646
  12. demonstrated regulation of endogenous CaMKIV by T3 in embryonic stem (ES) cells differentiated into neurons and identified a single complex element in the CaMKIV 5'-flanking region that confers this regulation PMID: 12403833
  13. Thr196 phosphorylation of CaM-KIV by CaM-KK reduces interaction of the catalytic core with the autoinhibitory region, resulting in generation of the autonomous activity PMID: 15262966
  14. the CaM-KK-CaM-KIV cascade probably plays an important role in thyroid releasing hormone induction of thyroid stimulating hormone and prolactin transcriptional activity in pituitary cells. PMID: 15308608
  15. study establishes nuclear m-calpain as a regulator of CaMKIV and associated signaling molecules under conditions of sustained Ca(2+) influx PMID: 15537635
  16. Expression of active CaMKIV caused an enhancement of both NMDA receptor-mediated synaptic responses and long-term potentiation. This was accompanied by changes consistent with the generation of "silent synapses". PMID: 15748849
  17. CaMKIV signaling stimulates vitamin D receptor (VDR)-mediated transcription by PMID: 15919723
  18. These results suggest that a signaling mechanism that involves CaMKIV/PKD and PP2A controls YY1 function through regulation of HDAC5 and is important in the maintenance of muscle differentiation. PMID: 16822951
  19. Lithium administration reduced CREB phosphorylation and at the same time down-regulated CaMKIV (enzymatic activity, phospho-Thr196 and protein expression level) in cell nuclei from the hippocampus. PMID: 16923323
  20. Calcineurin A and CaMKIV triggers PGC-1alpha promoter transactivation to drive the expression of non-mitochondrial proteins. PMID: 17273866
  21. CaMKIV activates OGT (o-linked GlcNAc transferase), and OGT has an essential role on the process of CaMKIV-dependent AP-1 activation under depolarization in neuronal cells. PMID: 18029144
  22. Activation of calcium/calmodulin-dependent kinase IV is necessary for brain-derived neurotrophic factor (BDNF)-induced phosphorylation of CREB and subsequent block of myelin-mediated inhibition of axonal growth. PMID: 18381242
  23. TRPC6, a member of the TRPC family, promotes hippocampal neuron dendritic growth. PMID: 18559891
  24. analysis of regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification PMID: 19506079
  25. CaMKIV is regulated by the Wnt signaling pathway. CaMKIV expression could play a role in the neuroprotective function of Wnt signaling against the Alzheimer's amyloid peptide. PMID: 19711354

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Subcellular Location Cytoplasm. Nucleus.
Protein Families Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
Tissue Specificity Isoform 1 is expressed in brain and isoform 2 is testis specific.
Database Links

KEGG: rno:25050

STRING: 10116.ENSRNOP00000027771

UniGene: Rn.11046

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