Recombinant Rat Calcium/calmodulin-dependent protein kinase type IV (Camk4)

Code CSB-EP004471RA
Size US$306
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Greater than 90% as determined by SDS-PAGE.
Target Names
Uniprot No.
Research Area
Alternative Names
Camk4; Calcium/calmodulin-dependent protein kinase type IV; CaMK IV; EC; CaM kinase-GR; Calspermin
Rattus norvegicus (Rat)
Expression Region
Target Protein Sequence
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight
Protein Length
Full Length
Tag Info
N-terminal 6xHis-tagged
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.

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Target Background

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.; Heat-stable, acidic, calmodulin-binding protein.
Gene References into Functions
  1. study demonstrates that CaMKIV can relieve STZ-induced diabetic neuropathic pain.pCaMKIV can regulate the expression of High-mobility group box 1 based on both cellular and animal models. PMID: 27216039
  2. We find that synaptic excitation and intrinsic excitability are coregulated in individual neurons through CaMKIV signaling, which is tightly controlled by neuronal activity. In contrast, synaptic inhibition is unaffected by changes in firing or CaMKIV signaling in individual neurons. PMID: 28592691
  3. Camk4 expression in the cortical subplate was prolonged in developmentally hypothyroid pups, whereas heavy Camk4 expression in layer VIb remains at P60. Abnormal expression of Camk4 might cause altered cortical connectivity. PMID: 23680840
  4. We have determined that high levels of CaMKIV protein are expressed by IB4-binding sensory neurons of the dorsal root ganglion PMID: 23817991
  5. CaMKIV contributes to the diversity of dendrite arbors via restricted expression and regulation of distinct modes of dendrite elaboration. PMID: 21989476
  6. These results suggest that NR2B-containing NMDARs have a positive role in regulating neural progenitor cell proliferation, which may be mediated through CaMKIV phosphorylation and subsequent induction of CREB activation. PMID: 21762679
  7. Study provides correlative evidence for the neuroprotective cascade of CaMKIV/ peroxisome proliferator-activated receptor gamma coactivator-1alpha in delayed neuronal cell death and mitochondrial biogenesis in the hippocampus PMID: 20799369
  8. abnormal regulation of CaMKIV is a component of beta-cell dysfunction caused by high glucose. PMID: 20423744
  9. Activation of the CaMKK/CaMKIV cascade by exendin-4 stimulated ABCA1 gene transcription, indicating that exendin-4 plays an important role in insulin secretion and cholesterol ester content in pancreatic beta cells. PMID: 19874424
  10. Camk4 is regulated directly by triiodothyronine in primary cultured neurons from fetal cortex, and the Camk4 protein is also induced by thyroid hormone. PMID: 20056827
  11. Calcium-induced dendritic growth is regulated by activation of a transcriptional program that involves CaM kinase IV-mediated signaling to the nucleus. PMID: 12086646
  12. demonstrated regulation of endogenous CaMKIV by T3 in embryonic stem (ES) cells differentiated into neurons and identified a single complex element in the CaMKIV 5'-flanking region that confers this regulation PMID: 12403833
  13. Thr196 phosphorylation of CaM-KIV by CaM-KK reduces interaction of the catalytic core with the autoinhibitory region, resulting in generation of the autonomous activity PMID: 15262966
  14. the CaM-KK-CaM-KIV cascade probably plays an important role in thyroid releasing hormone induction of thyroid stimulating hormone and prolactin transcriptional activity in pituitary cells. PMID: 15308608
  15. study establishes nuclear m-calpain as a regulator of CaMKIV and associated signaling molecules under conditions of sustained Ca(2+) influx PMID: 15537635
  16. Expression of active CaMKIV caused an enhancement of both NMDA receptor-mediated synaptic responses and long-term potentiation. This was accompanied by changes consistent with the generation of "silent synapses". PMID: 15748849
  17. CaMKIV signaling stimulates vitamin D receptor (VDR)-mediated transcription by PMID: 15919723
  18. These results suggest that a signaling mechanism that involves CaMKIV/PKD and PP2A controls YY1 function through regulation of HDAC5 and is important in the maintenance of muscle differentiation. PMID: 16822951
  19. Lithium administration reduced CREB phosphorylation and at the same time down-regulated CaMKIV (enzymatic activity, phospho-Thr196 and protein expression level) in cell nuclei from the hippocampus. PMID: 16923323
  20. Calcineurin A and CaMKIV triggers PGC-1alpha promoter transactivation to drive the expression of non-mitochondrial proteins. PMID: 17273866
  21. CaMKIV activates OGT (o-linked GlcNAc transferase), and OGT has an essential role on the process of CaMKIV-dependent AP-1 activation under depolarization in neuronal cells. PMID: 18029144
  22. Activation of calcium/calmodulin-dependent kinase IV is necessary for brain-derived neurotrophic factor (BDNF)-induced phosphorylation of CREB and subsequent block of myelin-mediated inhibition of axonal growth. PMID: 18381242
  23. TRPC6, a member of the TRPC family, promotes hippocampal neuron dendritic growth. PMID: 18559891
  24. analysis of regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification PMID: 19506079
  25. CaMKIV is regulated by the Wnt signaling pathway. CaMKIV expression could play a role in the neuroprotective function of Wnt signaling against the Alzheimer's amyloid peptide. PMID: 19711354

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Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
Tissue Specificity
Isoform 1 is expressed in brain and isoform 2 is testis specific.
Database Links
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