Clec12a Antibody

1. The effects of CLEC12A blocking were further validated using CLEC12A knockout (KO) animals wherein EAE disease induction was delayed and reduced disease severity was observed. These studies reveal the utility of a DC-specific mechanism in designing new therapeutics for MS. PMID: 28578388
2. Clec9A and Clec12A exhibit different intrinsic capacities to elicit MHC I and MHC II presentation following direct antigen targeting PMID: 27978488
3. Clec12a(-/-) mice are more susceptible to Salmonella infection, supporting a role for CLEC12A in antibacterial defense pathways in vivo. PMID: 26095365
4. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. PMID: 24631154
5. the molecular cloning, tissue distribution, and functional characterization of a novel NK cell receptor, KLRL1, from human and mouse dendritic cells [KLRL1] PMID: 15238421
6. CLL-1 expression is also present on the CD34(+)CD38(-) stem- cell compartment in acute myeloid leukemia PMID: 17609428
7. mMICL recognises an endogenous ligand in a variety of murine tissues, suggesting that the receptor plays a role in homeostasis PMID: 18350551
8. Anti-Clec12A mAb alone produced only moderate responses, but these were amplified by coinjecting only small amounts of LPS as a dendritic cell activation agent PMID: 19494282

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KEGG: mmu:232413

STRING: 10090.ENSMUSP00000063627

UniGene: Mm.90241