Clec12a Antibody

Code CSB-PA709488ZA01MO
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Product Details

Full Product Name
Rabbit anti-Mus musculus (Mouse) Clec12a Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Clec12a antibody; MiclC-type lectin domain family 12 member A antibody; C-type lectin-like molecule 1 antibody; CLL-1 antibody; Myeloid inhibitory C-type lectin-like receptor antibody; MICL antibody; CD antigen CD371 antibody
Raised in
Species Reactivity
Mus musculus
Recombinant Mus musculus Clec12a protein
Immunogen Species
Mus musculus (Mouse)
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
Gene References into Functions
  1. The effects of CLEC12A blocking were further validated using CLEC12A knockout (KO) animals wherein EAE disease induction was delayed and reduced disease severity was observed. These studies reveal the utility of a DC-specific mechanism in designing new therapeutics for MS. PMID: 28578388
  2. Clec9A and Clec12A exhibit different intrinsic capacities to elicit MHC I and MHC II presentation following direct antigen targeting PMID: 27978488
  3. Clec12a(-/-) mice are more susceptible to Salmonella infection, supporting a role for CLEC12A in antibacterial defense pathways in vivo. PMID: 26095365
  4. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. PMID: 24631154
  5. the molecular cloning, tissue distribution, and functional characterization of a novel NK cell receptor, KLRL1, from human and mouse dendritic cells [KLRL1] PMID: 15238421
  6. CLL-1 expression is also present on the CD34(+)CD38(-) stem- cell compartment in acute myeloid leukemia PMID: 17609428
  7. mMICL recognises an endogenous ligand in a variety of murine tissues, suggesting that the receptor plays a role in homeostasis PMID: 18350551
  8. Anti-Clec12A mAb alone produced only moderate responses, but these were amplified by coinjecting only small amounts of LPS as a dendritic cell activation agent PMID: 19494282

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Subcellular Location
Cell membrane; Single-pass type II membrane protein.
Database Links
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